Evidence map›Paper›PMID 25771815›Full record

ArticleEye (London, England)2015

Gene-gene interaction of CFH, ARMS2, and ARMS2/HTRA1 on the risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in Chinese population.

L Huang, Q Meng, C Zhang, Y Sun, Y Bai, S Li, X Deng, B Wang, W Yu, M Zhao and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration.International journal of molecular sciences · 2021
    Review
  2. The association of polypoidal choroidal vasculopathy clinical phenotypes with previously reported genetic markers.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Article
  3. Article
  4. Review
  5. AMD Genetics in India: The Missing Links.Frontiers in aging neuroscience · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

L Huang1] Department of Ophthalmology, Peking University People's Hospital, Beijing, China [2] Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China [3] Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Q Meng1] Department of Ophthalmology, Peking University People's Hospital, Beijing, China [2] Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China [3] Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
C ZhangDepartment of Clinical Epidemiology, Peking University People's Hospital, Beijing, China.
Y Sun1] Department of Ophthalmology, Peking University People's Hospital, Beijing, China [2] Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China [3] Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Y Bai1] Department of Ophthalmology, Peking University People's Hospital, Beijing, China [2] Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China [3] Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
S Li1] Department of Ophthalmology, Peking University People's Hospital, Beijing, China [2] Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China [3] Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
X Deng1] Department of Ophthalmology, Peking University People's Hospital, Beijing, China [2] Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China [3] Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
B Wang1] Department of Ophthalmology, Peking University People's Hospital, Beijing, China [2] Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China [3] Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
W Yu1] Department of Ophthalmology, Peking University People's Hospital, Beijing, China [2] Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China [3] Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
M Zhao1] Department of Ophthalmology, Peking University People's Hospital, Beijing, China [2] Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China [3] Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
X Li1] Department of Ophthalmology, Peking University People's Hospital, Beijing, China [2] Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China [3] Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Peking University · CNMinistry of Education of the People's Republic of China · CNPeking University People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the association and interaction of five single-nucleotide polymorphisms (SNPs) in three genes (CFH, ARMS2, and ARMS2/HTRA1) with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in Chinese population.

methodsA total of 300 nAMD and 300 PCV patients and 301 normal subjects participated in the present study. The allelic variants of rs800292, rs2274700, rs3750847, rs3793917, and rs1065489 were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Gene-gene interactions were evaluated by the data mining approach multifactor-dimensionality reduction (MDR) method.

resultsThe risk alleles of CFH rs800292, rs2274700, ARMS2 rs3057847, and ARMS2/HTRA1 rs3793917 showed significant difference between nAMD or PCV patients and controls (all P<0.01). The homozygosity of risk alleles for rs800292, rs2274700, rs3750847, and rs3793917 were significantly different between nAMD patients and controls (all P<0.01), and predisposed to PCV patients (all P<0.01). After cross-validation consistency (CVC) and permutation tests, the two-locus model rs2274700_rs3750847 has a balanced accuracy of 64.37% in predicting nAMD disease risk. The one-marker model, rs3750847, and two-locus model rs2274700_rs3750847 has a balanced accuracy of 66.07% and 65.89% in predicting PCV disease risk, respectively. Furthermore, CFH rs1065489 did not show significant association with nAMD (P>0.01), but was strongly associated with PCV in Chinese patients (P<0.001).

conclusionsIn this study, we found that the interaction of ARMS2 and ARMS2/HTRA1 is significantly associated with nAMD, and the interaction of CFH and ARMS2 is pronounced in PCV development in Chinese population.

Indexed as

AdultAgedAged, 80 and overAsian PeopleChinaChoroidal NeovascularizationComplement Factor HEpistasis, GeneticFemaleFluorescein AngiographyGene FrequencyGenotypeHigh-Temperature Requirement A Serine Peptidase 1HumansMaleMiddle AgedARMS2 protein, humanCFH protein, humanComplement Factor HHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, humanProteinsSerine Endopeptidases

Identifiers

PMID25771815
PMCPMC4429281
OpenAlexW1995802077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.