Evidence map›Paper›PMID 25771800›Full record

ArticleExperimental neurology2015

Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke.

Wenting Zhang, Hailian Wang, Hui Zhang, Rehana K Leak, Yejie Shi, Xiaoming Hu, Yanqin Gao, Jun Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Marine-derived n-3 fatty acids therapy for stroke.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Marine-derived n-3 fatty acids therapy for stroke.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Optimized mouse model of embolic MCAO: From cerebral blood flow to neurological outcomes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Neuroprotection ofMolecules (Basel, Switzerland) · 2021
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Preconditioning with partial caloric restriction confers long-term protection against grey and white matter injury after transient focal ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Wenting ZhangState Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, and Departments of Anesthesiology and Neurology of Huashan Hospital, Fudan University, Shanghai 200032, China; Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: wtzhang@fudan.edu.cn.
Hailian WangState Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, and Departments of Anesthesiology and Neurology of Huashan Hospital, Fudan University, Shanghai 200032, China.
Hui ZhangState Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, and Departments of Anesthesiology and Neurology of Huashan Hospital, Fudan University, Shanghai 200032, China.
Rehana K LeakDivision of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Yejie ShiCenter of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA.
Xiaoming HuState Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, and Departments of Anesthesiology and Neurology of Huashan Hospital, Fudan University, Shanghai 200032, China; Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA.
Yanqin GaoState Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, and Departments of Anesthesiology and Neurology of Huashan Hospital, Fudan University, Shanghai 200032, China; Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Jun ChenState Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, and Departments of Anesthesiology and Neurology of Huashan Hospital, Fudan University, Shanghai 200032, China; Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA. Electronic address: chenj2@upmc.edu.
State Key Laboratory of Medical NeurobiologyUniversity of Pittsburgh · USGeriatric Research Education and Clinical Center · USMylan (United States) · US

Funding

INDUCIBLE DNA REPAIR IN CEREBRAL ISCHEMIAR01NS036736 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENNETT, MICHAEL V L, GRAHAM, STEVEN H · 1997 to 2021
$5.4M
Neuroprotection in Models of Cerebral IschemiaR01NS045048 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, JUN · 2003 to 2015
$3.1M
Programmed Cell Death Induced by Cerebral IschemiaR01NS043802 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, JUN · 2002 to 2006
$1.4M
Molecular therapies to enhance brain recovery after experimental strokeI01RX000420 · VA · VETERANS HEALTH ADMINISTRATION · PI CHEN, JUN · 2012 to 2014
–
NINDS NIH HHS NS36736NINDS NIH HHS NS43802NINDS NIH HHS NS45048NINDS NIH HHS R01 NS036736NINDS NIH HHS R01 NS043802NINDS NIH HHS R01 NS045048RRD VA I01 RX000420
6 · The paper itself

Abstract

Stroke is a devastating neurological disease with no satisfactory therapies to preserve long-term neurological function, perhaps due to the sole emphasis on neuronal survival in most preclinical studies. Recent studies have revealed the importance of protecting multiple cell types in the injured brain, such as oligodendrocytes and components of the neurovascular unit, before long-lasting recovery of function can be achieved. For example, revascularization in the ischemic penumbra is critical to provide various neurotrophic factors that enhance the survival and activity of neurons and other progenitor cells, such as oligodendrocyte precursor cells. In the present study, we hypothesized that chronic dietary supplementation with fish oil promotes post-stroke angiogenesis, neurogenesis, and oligodendrogenesis, thereby leading to long-term functional improvements. Mice received dietary supplementation with n-3 PUFA-enriched fish oil for three months before and up to one month after stroke. As expected, dietary n-3 PUFAs significantly increased levels of n-3 PUFAs in the brain and improved long-term behavioral outcomes after cerebral ischemia. n-3 PUFAs also robustly improved revascularization and angiogenesis and boosted the survival of NeuN/BrdU labeled newborn neurons up to 35days after stroke injury. Furthermore, these pro-neurogenic effects were accompanied by robust oligodendrogenesis. Thus, this is the first study to demonstrate that chronic dietary intake of n-3 PUFAs is an effective prophylactic measure not only to protect against ischemic injury for the long term but also to actively promote neurovascular restorative dynamics and brain repair.

Indexed as

Dietary SupplementsAnalysis of VarianceAnimalsBromodeoxyuridineCell ProliferationCerebrovascular CirculationDisease Models, AnimalDoublecortin Domain ProteinsFatty AcidsFatty Acids, Omega-3Infarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLMicrotubule-Associated ProteinsMotor ActivityBromodeoxyuridineDoublecortin Domain ProteinsFatty AcidsFatty Acids, Omega-3Microtubule-Associated ProteinsNeuropeptidesPhosphopyruvate HydrataseAngiogenesisAngiopoietin 1Docosahexaenoic acidEicosapentaenoic acidNeurogenesisOligodendrocyte precursor cellOligodendrogenesisRevascularization

Identifiers

PMID25771800
PMCPMC4567974
OpenAlexW2062098709

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.