ArticleBipolar disorders2015
Emotion regulation deficits in euthymic bipolar I versus bipolar II disorder: a functional and diffusion-tensor imaging study.
Article in Bipolar disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.Brain and behavior · 2026Pooled it
- The uncinate fasciculus in individuals with and at risk for bipolar disorder: A meta-analysis.Journal of affective disorders · 2022Pooled it
- Gray matter bases of psychotic features in adult bipolar disorder: A systematic review and voxel-based meta-analysis of neuroimaging studies.Human brain mapping · 2018Pooled it
- Moral emotion processing in euthymic bipolar disorder: insights from network analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Differences in biochemical metabolism and cognitive function between bipolar I and bipolar II disorder.BMC psychiatry · 2026Observational
- White Matter Abnormalities in Bipolar II and Unipolar Depression - Evidence from Fixel-Based Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Working memory network dysfunction in bipolar I vs. bipolar II disorder: a systematic review of task-fMRI evidence.Frontiers in psychiatry · 2026Review
- White and gray matter alterations in bipolar I and bipolar II disorder subtypes compared with healthy controls - exploring associations with disease course and polygenic risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders.Neuronal signaling · 2023Review
- Perceiving visual negative stimuli in schizophrenia and bipolar disorder: Meta-analytic evidence of a common altered thalamic-parahippocampal-basal ganglia circuit.Neuroimage. Reports · 2023Article
- Normalization of impaired emotion inhibition in bipolar disorder mediated by cholinergic neurotransmission in the cingulate cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- White Matter Correlates of Early-Onset Bipolar Illness and Predictors of One-Year Recurrence of Depression in Adults with Bipolar Disorder.Journal of clinical medicine · 2022Article
- White matter predictors of worsening of subthreshold hypomania severity in non-bipolar young adults parallel abnormalities in individuals with bipolar disorder.Journal of affective disorders · 2022Article
- A graph theory-based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder.Bipolar disorders · 2022Article
- Comparison of Patterns of Non-suicidal Self-Injury and Emotion Dysregulation Across Mood Disorder Subtypes.Frontiers in psychiatry · 2022Article
- Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review.Journal of psychiatry and brain science · 2022Article
- Deficits in explicit emotion regulation in bipolar disorder: a systematic review.International journal of bipolar disorders · 2021Review
- White matter abnormalities in adults with bipolar disorder type-II and unipolar depression.Scientific reports · 2021Article
- Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder.Bipolar disorders · 2021Article
- Common and Specific Characteristics of Adolescent Bipolar Disorder Types I and II: A Combined Cortical Thickness and Structural Covariance Analysis.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
objectivesEmotion regulation deficits are a core feature of bipolar disorder. However, their potential neurobiological underpinnings and existence beyond bipolar I disorder remain unexplored. Our main goal was to investigate whether both individuals with bipolar I and bipolar II disorder show deficits in emotion regulation during an attention control task, and to explore the neurophysiological underpinnings of this potential deficit.
methodsTwenty healthy controls, 16 euthymic participants with bipolar I disorder, and 19 euthymic participants with bipolar II disorder completed psychometric and clinical assessments, a neuroimaging emotion regulation paradigm, and an anatomical diffusion-weighted scan. Groups were matched for age, gender, and verbal IQ.
resultsDuring the presence of emotional distracters, subjects with bipolar I disorder showed slowed reaction times to targets, and increased blood oxygenation level-dependent (BOLD) responses in the amygdala, accumbens, and dorsolateral prefrontal cortex, but not increased inverse functional connectivity between these prefrontal and subcortical areas, and altered white matter microstructure organization in the right uncinate fasciculus. Subjects with bipolar II disorder showed no altered reaction times, increased BOLD responses in the same brain areas, increased inverse functional connectivity between the prefrontal cortex and amygdala, and no abnormalities in white matter organization.
conclusionsParticipants with bipolar I disorder showed abnormalities in functional and anatomical connectivity between prefrontal cortices and subcortical structures in emotion regulation circuitry. However, these deficits did not extend to subjects with bipolar II disorder, suggesting fundamental differences in the pathophysiology of bipolar disorder subtypes.
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