ArticleNeurobiology of aging2015
Normal-appearing cerebral white matter in healthy adults: mean change over 2 years and individual differences in change.
Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults.Neuroscience and biobehavioral reviews · 2018Pooled it
- Trial
- A comparative study of risk factors in predictive models for cognitive dysfunction in patients with leukoaraiosis based on machine learning algorithms.Frontiers in neuroscience · 2025Article
- Article
- Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging.bioRxiv : the preprint server for biology · 2023Article
- Instructing Use of an Effective Strategy Improves Recognition Memory in Healthy Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Age-Related Hearing Loss, Cognitive Performance, and Metabolic Risk in Healthy Adults: A Seven-Year Longitudinal Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Diffusion Tensor and Kurtosis Imaging Findings the First Year following Mild Traumatic Brain Injury.Journal of neurotrauma · 2023Article
- Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults.Cerebral circulation - cognition and behavior · 2023Article
- Apolipoprotein E ε4 Mediates Myelin Breakdown by Targeting Oligodendrocytes in Sporadic Alzheimer Disease.Journal of neuropathology and experimental neurology · 2022Article
- White matter fiber-specific degeneration in older adults with metabolic syndrome.Molecular metabolism · 2022Article
- The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Higher BMI, but not obesity-related genetic polymorphisms, correlates with lower structural connectivity of the reward network in a population-based study.International journal of obesity (2005) · 2021Article
- Microstructure of Human Corpus Callosum across the Lifespan: Regional Variations in Axon Caliber, Density, and Myelin Content.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health.Frontiers in aging neuroscience · 2021Article
- Lasting consequences of concussion on the aging brain: Findings from the Baltimore Longitudinal Study of Aging.NeuroImage · 2020Article
- Is the Brain an Early or Late Component of Essential Hypertension?American journal of hypertension · 2020Review
- Hippocampal Subfields and Limbic White Matter Jointly Predict Learning Rate in Older Adults.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Reproducibility, reliability and variability of FA and MD in the older healthy population: A test-retest multiparametric analysis.NeuroImage. Clinical · 2020Article
- Metabolic risk affects fluid intelligence changes in healthy adults.Psychology and aging · 2019Article
Corrections and comments
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2 authors.
Funding
Abstract
Diffusion tensor imaging studies show age-related differences in cerebral white matter (WM). However, few have studied WM changes over time, and none evaluated individual differences in change across a wide age range. Here, we examined 2-year WM change in 96 healthy adults (baseline age, 19-78 years), individual differences in change, and the influence of vascular and metabolic risk thereon. Fractional anisotropy (FA), axial diffusivity, and radial diffusivity (RD) represented microstructural properties of normal-appearing WM within 13 regions. Cross-sectional analyses revealed age-related differences in all WM indices across the regions. In contrast, latent change score analyses showed longitudinal declines in axial diffusivity in association and projection fibers and increases in anterior commissural fibers. FA and RD evidenced a less consistent pattern of change. Metabolic risk mediated the effects of age on FA and RD change in corpus callosum body and dorsal cingulum. These findings underscore the importance of longitudinal studies in evaluating individual differences in change and the role of metabolic factors in shaping trajectories of brain aging.
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