SynthesisCerebral cortex (New York, N.Y. : 1991)2015
The Roles of Left Versus Right Anterior Temporal Lobes in Conceptual Knowledge: An ALE Meta-analysis of 97 Functional Neuroimaging Studies.
Synthesis in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
149 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Role of the Right Language Network and the Multiple-Demand Network in Verbal Semantics: Insights From an Activation Likelihood Estimation Meta-Analysis of 561 Functional Neuroimaging Studies.Human brain mapping · 2025Pooled it
- Multiple dimensions underlying the functional organization of the language network.NeuroImage · 2021Pooled it
- The neural correlates of semantic control revisited.NeuroImage · 2021Pooled it
- Trial
- Acute Modulation of Brain Connectivity in Parkinson Disease after Automatic Mechanical Peripheral Stimulation: A Pilot Study.PloS one · 2015Trial
- Heritable and experience-dependent cortical traits of reading ability.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Unifying Divergent Conceptions in Nonfluent/Agrammatic and Semantic Primary Progressive Aphasia.Brain sciences · 2026Review
- Bridging Continuous and Discrete Models of the Anterior Temporal Lobe via Cortical Gradients.Research square · 2026Article
- The Anterior Temporal Semantic Hub in the Left and Right Hemispheres: A Unitary System or Two Separate Systems for Meaning?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- From Sensory Details to Verbal Codes: Visual Memory Reinstatement of Location and Color Features.bioRxiv : the preprint server for biology · 2026Article
- Atypical development of white matter structural networks in children and adolescents with autism spectrum disorder: a graph theory study.Frontiers in neuroscience · 2026Article
- Controlled Semantic Cognition: Precision Recordings Converge With in Silico Experiments to Reveal the Inner Workings of the Anterior Temporal Lobe Hub.Neurobiology of language (Cambridge, Mass.) · 2026Review
- Multimodal MRI links gray matter volume loss and temporal lobe susceptibility to CSF immunological profiles in Guillain-Barré syndrome.Frontiers in immunology · 2026Article
- Overlapping and distinct intrinsic connectivity of hippocampal and triple networks in autistic individuals with and without a comorbid condition of ADHD.Frontiers in psychiatry · 2026Article
- Separating the forest from the palm trees: Individual variation in a presurgical language mapping task.NeuroImage. Clinical · 2026Article
- The Role of the Anterior Temporal Lobe in Reading: An HD-tDCS Study.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Lesion-Symptom Mapping of Acute Speech Deficits After Left vs. Right Hemisphere Stroke: A Retrospective Analysis of NIHSS Best Language Scores and Clinical Neuroimaging.Brain sciences · 2025Article
- Neural Tracking of Race-Related Information During Face Perception.Neuroscience bulletin · 2025Article
- The neural correlates of novel versus familiar metaphors in healthy young adults: A functional near-infrared spectroscopy study.bioRxiv : the preprint server for biology · 2025Article
- Motor expertise shapes crossmodal and modality-specific action representations in table tennis players.Behavioral and brain functions : BBF · 2025Article
89 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
The roles of the right and left anterior temporal lobes (ATLs) in conceptual knowledge are a source of debate between 4 conflicting accounts. Possible ATL specializations include: (1) Processing of verbal versus non-verbal inputs; (2) the involvement of word retrieval; and (3) the social content of the stimuli. Conversely, the "hub-and-spoke" account holds that both ATLs form a bilateral functionally unified system. Using activation likelihood estimation (ALE) to compare the probability of left and right ATL activation, we analyzed 97 functional neuroimaging studies of conceptual knowledge, organized according to the predictions of the three specialized hypotheses. The primary result was that ATL activation was predominately bilateral and highly overlapping for all stimulus types. Secondary to this bilateral representation, there were subtle gradations both between and within the ATLs. Activations were more likely to be left lateralized when the input was a written word or when word retrieval was required. These data are best accommodated by a graded version of the hub-and-spoke account, whereby representation of conceptual knowledge is supported through bilateral yet graded connectivity between the ATLs and various modality-specific sensory, motor, and limbic cortices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.