Evidence map›Paper›PMID 25771169›Full record

ArticleNeurobiology of disease2015

Interrogating the aged striatum: robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration.

Timothy J Collier, Jennifer O'Malley, David J Rademacher, Jennifer A Stancati, Kellie A Sisson, Caryl E Sortwell, Katrina L Paumier, Kibrom G Gebremedhin, Kathy Steece-Collier

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Graft ischemia post cell transplantation to the brain: Glucose deprivation as the primary driver of rapid cell death.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Downregulation of striatal CaNeurobiology of disease · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Cell therapy for Parkinson's disease: Why it doesn't work every time.Movement disorders : official journal of the Movement Disorder Society · 2019
    Article
  13. Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2019
    Article
  14. Aging and Parkinson's disease: Different sides of the same coin?Movement disorders : official journal of the Movement Disorder Society · 2017
    Review
  15. Article
  16. Article
  17. Article
  18. Impact of age and vector construct on striatal and nigral transgene expression.Molecular therapy. Methods & clinical development · 2016
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Timothy J CollierMichigan State University, College of Human Medicine, Department of Translational Science and Molecular Medicine & The Udall Center of Excellence in Parkinson's Disease Research, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Jennifer O'MalleyCincinnati Children's Hospital Medical Center, Division of Child Neurology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
David J RademacherLake Forest College, Department of Psychology, 555 N Sheridan Rd, Lake Forest, IL 60045, USA.
Jennifer A StancatiMichigan State University, College of Human Medicine, Department of Translational Science and Molecular Medicine & The Udall Center of Excellence in Parkinson's Disease Research, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Kellie A SissonMichigan State University, College of Human Medicine, Department of Translational Science and Molecular Medicine & The Udall Center of Excellence in Parkinson's Disease Research, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Caryl E SortwellMichigan State University, College of Human Medicine, Department of Translational Science and Molecular Medicine & The Udall Center of Excellence in Parkinson's Disease Research, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Katrina L PaumierMichigan State University, College of Human Medicine, Department of Translational Science and Molecular Medicine & The Udall Center of Excellence in Parkinson's Disease Research, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Kibrom G GebremedhinMichigan State University, College of Human Medicine, Department of Translational Science and Molecular Medicine & The Udall Center of Excellence in Parkinson's Disease Research, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Kathy Steece-CollierMichigan State University, College of Human Medicine, Department of Translational Science and Molecular Medicine & The Udall Center of Excellence in Parkinson's Disease Research, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA. Electronic address: kathy.steece-collier@hc.msu.edu.
Michigan State University · USCincinnati Children's Hospital Medical Center · USLake Forest College · US

Funding

STN Deep Brain Stimulation and NeuroprotectionP50NS058830 · NINDS · UNIVERSITY OF CINCINNATI · PI COLLIER, TIMOTHY J. · 2009 to 2015
$5.9M
LEVODOPA DYSKINESIAS: IMPACT OF DOPAMINE NEURONSR01NS045132 · NINDS · UNIVERSITY OF CINCINNATI · PI STEECE-COLLIER, KATHY · 2003 to 2011
$2.1M
Aberrant Synaptic Plasticity: Impact of Dopamine on Graft OutcomeR56NS045132 · NINDS · UNIVERSITY OF CINCINNATI · PI STEECE-COLLIER, KATHY · 2008 to 2008
$403k
NINDS NIH HHS P50 NS058830NINDS NIH HHS R01 NS04513NINDS NIH HHS R01 NS045132NINDS NIH HHS R56 NS045132
6 · The paper itself

Abstract

Advanced age is the primary risk factor for Parkinson's disease (PD). In PD patients and rodent models of PD, advanced age is associated with inferior symptomatic benefit following intrastriatal grafting of embryonic dopamine (DA) neurons, a pattern believed to result from decreased survival and reinnervation provided by grafted neurons in the aged host. To help understand the capacity of the aged, parkinsonian striatum to be remodeled with new DA terminals, we used a grafting model and examined whether increasing the number of grafted DA neurons in aged rats would translate to enhanced behavioral recovery. Young (3months), middle-aged (15months), and aged (22months) parkinsonian rats were grafted with proportionately increasing numbers of embryonic ventral mesencephalic (VM) cells to evaluate whether the limitations of the graft environment in subjects of advancing age can be offset by increased numbers of transplanted neurons. Despite robust survival of grafted neurons in aged rats, reinnervation of striatal neurons remained inferior and amelioration of levodopa-induced dyskinesias (LID) was delayed or absent. This study demonstrates that: 1) counter to previous evidence, under certain conditions the aged striatum can support robust survival of grafted DA neurons; and 2) unknown factors associated with the aged striatum result in inferior integration of graft and host, and continue to present obstacles to full therapeutic efficacy of DA cell-based therapy in this model of aging.

Indexed as

AgingAmphetamineAnimalsCorpus StriatumDisease Models, AnimalDopamine and cAMP-Regulated Phosphoprotein 32Dopaminergic NeuronsDyskinesia, Drug-InducedEmbryo, MammalianFunctional LateralityLevodopaNeuritesOxidopamineParkinson DiseaseProto-Oncogene Proteins c-fosRatsAmphetamineDopamine and cAMP-Regulated Phosphoprotein 32Fosb protein, ratLevodopaOxidopamineProto-Oncogene Proteins c-fosSubstance PAgingDyskinesiasGraftingLevodopaParkinson's diseaseRodentSynaptopodin

Identifiers

PMID25771169
PMCPMC4402284
OpenAlexW2085120609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.