ReviewVeterinary microbiology2015
Animal models to study the pathogenesis of human and animal Clostridium perfringens infections.
Review in Veterinary microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 75 citations in OpenAlex.
- Protective antigens hidden in the bovine Clostridium vaccine.Frontiers in immunology · 2026Article
- Liver-Microbiome Crosstalk Mediates the Protective Effects of Artemisinin in Clostridium perfringens Models.Microbial biotechnology · 2025Article
- Effect ofNAM journal · 2025Article
- Exploring the predictive power of jejunal microbiome composition in clinical and subclinical necrotic enteritis caused by Clostridium perfringens: insights from a broiler chicken model.Journal of translational medicine · 2024Article
- Steamed broccoli sprouts alleviate DSS-induced inflammation and retain gut microbial biogeography in mice.bioRxiv : the preprint server for biology · 2023Article
- Reduction of Pathogens in Feces and Lymph Nodes Collected from Beef Cattle FedFoods (Basel, Switzerland) · 2022Article
- Phytic Acid againstFoods (Basel, Switzerland) · 2022Article
- Effect of PorcineFrontiers in veterinary science · 2022Article
- TMT labeled comparative proteomic analysis reveals spleen active immune responses duringPeerJ · 2022Article
- Establishment and evaluation of a specific antibiotic-induced inflammatory bowel disease model in rats.PloS one · 2022Article
- Potential Solutions Using Bacteriophages against Antimicrobial Resistant Bacteria.Antibiotics (Basel, Switzerland) · 2021Review
- Experimental induction of necrotic enteritis with or without predisposing factors using netB positive Clostridium perfringens strains.Gut pathogens · 2021Article
- A study on fungal defensin against multidrug-resistant Clostridium perfringens and its treatment on infected poultry.Applied microbiology and biotechnology · 2021Article
- Friend or Foe? Impacts of Dietary Xylans, Xylooligosaccharides, and Xylanases on Intestinal Health and Growth Performance of Monogastric Animals.Animals : an open access journal from MDPI · 2021Review
- Progress on Gut Health Maintenance and Antibiotic Alternatives in Broiler Chicken Production.Frontiers in nutrition · 2021Review
- Prevalence, Genotypic and Phenotypic Characterization and Antibiotic Resistance Profile ofToxins · 2020Article
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Article
- Lung endothelial cells are sensitive to epsilon toxin from Clostridium perfringens.Veterinary research · 2020Article
- Using More Than 1 (Path)Way to Kill a Host Cell: Lessons FromMicrobiology insights · 2020Article
- Verbascoside Protects Mice From Clostridial Gas Gangrene by Inhibiting the Activity of Alpha Toxin and Perfringolysin O.Frontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The most common animal models used to study Clostridium perfringens infections in humans and animals are reviewed here. The classical C. perfringens-mediated histotoxic disease of humans is clostridial myonecrosis or gas gangrene and the use of a mouse myonecrosis model coupled with genetic studies has contributed greatly to our understanding of disease pathogenesis. Similarly, the use of a chicken model has enhanced our understanding of type A-mediated necrotic enteritis in poultry and has led to the identification of NetB as the primary toxin involved in disease. C. perfringens type A food poisoning is a highly prevalent bacterial illness in the USA and elsewhere. Rabbits and mice are the species most commonly used to study the action of enterotoxin, the causative toxin. Other animal models used to study the effect of this toxin are rats, non-human primates, sheep and cattle. In rabbits and mice, CPE produces severe necrosis of the small intestinal epithelium along with fluid accumulation. C. perfringens type D infection has been studied by inoculating epsilon toxin (ETX) intravenously into mice, rats, sheep, goats and cattle, and by intraduodenal inoculation of whole cultures of this microorganism in mice, sheep, goats and cattle. Molecular Koch's postulates have been fulfilled for enterotoxigenic C. perfringens type A in rabbits and mice, for C. perfringens type A necrotic enteritis and gas gangrene in chickens and mice, respectively, for C. perfringens type C in mice, rabbits and goats, and for C. perfringens type D in mice, sheep and goats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.