Evidence map›Paper›PMID 25770258›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2015

Role of resistant starch in improving gut health, adiposity, and insulin resistance.

Michael J Keenan, June Zhou, Maren Hegsted, Christine Pelkman, Holiday A Durham, Diana B Coulon, Roy J Martin

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 238 citations in OpenAlex.

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  15. Utilization of the enzyme pullulanase andBioscience of microbiota, food and health · 2026
    Article
  16. Enhancing Functional Properties and Shelf Life ofFoods (Basel, Switzerland) · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 1 country.

Michael J KeenanSchool of Nutrition and Food Sciences and mkeenan@agcenter.lsu.edu.
June ZhouGeriatric Endocrinology and Metabolism Laboratory, Veterans Affairs Medical Center, Washington, DC;
Maren HegstedDepartment of Food and Nutrition, University of Wisconsin-Stout, Menomonie, WI;
Christine PelkmanIngredion, Bridgewater, NJ;
Holiday A DurhamPennington Biomedical Research Center, Baton Rouge, LA; and.
Diana B CoulonBioassay Core Laboratory, Louisiana State University Agricultural Center, Baton Rouge, LA;
Roy J MartinWestern USDA Human Research Center, Davis, CA.
Food and Nutrition Service · USIngredion (United States) · USLouisiana State University Agricultural Center · USPennington Biomedical Research Center · USUniversity of Wisconsin–Stout · USVeterans Health Administration · USWestern Human Nutrition Research Center · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Dietary Resistant Starch: The role of PYY and GLP-1 in energy balanceR21DK073403 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MARTIN, ROY JOSEPH · 2006 to 2007
$399k
NIDDK NIH HHS R21 DK073403NIDDK NIH HHS R21 DK-073403-01A1NIGMS NIH HHS 1 U54 GM104940NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

The realization that low-glycemic index diets were formulated using resistant starch led to more than a decade of research on the health effects of resistant starch. Determination of the metabolizable energy of the resistant starch product allowed for the performance of isocaloric studies. Fermentation of resistant starch in rodent studies results in what appears to be a healthier gut, demonstrated by increased amounts of short-chain fatty acids, an apparent positive change in the microbiota, and increased gene expression for gene products involved in normal healthy proliferation and apoptosis of potential cancer cells. Additionally, consumption of resistant starch was associated with reduced abdominal fat and improved insulin sensitivity. Increased serum glucagon-like peptide 1 (GLP-1) likely plays a role in promoting these health benefits. One rodent study that did not use isocaloric diets demonstrated that the use of resistant starch at 8% of the weight of the diet reduced body fat. This appears to be approximately equivalent to the human fiber requirement. In human subjects, insulin sensitivity is increased with the feeding of resistant starch. However, only 1 of several studies reports an increase in serum GLP-1 associated with resistant starch added to the diet. This means that other mechanisms, such as increased intestinal gluconeogenesis or increased adiponectin, may be involved in the promotion of improved insulin sensitivity. Future research may confirm that there will be improved health if human individuals consume the requirement for dietary fiber and a large amount of the fiber is fermentable.

Indexed as

Abdominal FatDietInsulin ResistanceAdiposityAnimalsDietary FiberFatty Acids, VolatileFermentationGastrointestinal MicrobiomeGastrointestinal TractGlucagon-Like Peptide 1HumansObesity, AbdominalStarchDietary FiberFatty Acids, VolatileGlucagon-Like Peptide 1Starchfunctional foodsintestinal healthnurtigenomicsobesityresistant starch

Identifiers

PMID25770258
PMCPMC4352178
OpenAlexW2167525097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.