ArticleProceedings of the National Academy of Sciences of the United States of America2015
Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A novel SATB1 protein isoform with different biophysical properties.Frontiers in cell and developmental biology · 2023Article
- Single-cell detection of primary transcripts, their genomic loci and nuclear factors by 3D immuno-RNA/DNA FISH in T cells.Frontiers in immunology · 2023Article
- Identification of Prognostic lncRNA Related to the Immune Microenvironment of Soft Tissue Sarcoma.BioMed research international · 2022Article
- The role of lncRNAs in innate immunity and inflammation.RNA biology · 2021Review
- Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover.Nature cell biology · 2020Article
- Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.Journal of biosciences · 2020Article
- Long non-coding RNA expressed in macrophage co-varies with the inflammatory phenotype during macrophage development and polarization.Journal of cellular and molecular medicine · 2019Review
- The Role of Insulators in Transgene Transvection inGenetics · 2019Article
- Long non-coding RNAs regulating macrophage functions in homeostasis and disease.Vascular pharmacology · 2019Review
- Article
- Stochastic changes in gene expression promote chaotic dysregulation of homeostasis in clonal breast tumors.Communications biology · 2019Article
- Vertebrate GAF/ThPOK: emerging functions in chromatin architecture and transcriptional regulation.Cellular and molecular life sciences : CMLS · 2018Review
- The emerging landscape ofF1000Research · 2017Review
- Long non-coding RNA SeT and miR-155 regulate the Tnfα gene allelic expression profile.PloS one · 2017Article
- Pairing and anti-pairing: a balancing act in the diploid genome.Current opinion in genetics & development · 2016Review
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Physiological processes rely on the regulation of total mRNA levels in a cell. In diploid organisms, the transcriptional activation of one or both alleles of a gene may involve trans-allelic interactions that provide a tight spatial and temporal level of gene expression regulation. The mechanisms underlying such interactions still remain poorly understood. Here, we demonstrate that lipopolysaccharide stimulation of murine macrophages rapidly resulted in the actin-mediated and transient homologous spatial proximity of Tnfα alleles, which was necessary for the mono- to biallelic switch in gene expression. We identified two new complementary long noncoding RNAs transcribed from the TNFα locus and showed that their knockdown had opposite effects in Tnfα spatial proximity and allelic expression. Moreover, the observed spatial proximity of Tnfα alleles depended on pyruvate kinase muscle isoform 2 (PKM2) and T-helper-inducing POZ-Krüppel-like factor (ThPOK). This study suggests a role for lncRNAs in the regulation of somatic homologous spatial proximity and allelic expression control necessary for fine-tuning mammalian immune responses.
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