ArticleEMBO reports2015
The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells.
Article in EMBO reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Unbiased recording and identification of thymic cellular interactomes using synthetic Notch receptors.Nature communications · 2026Article
- T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025Review
- Synchronized development of thymic eosinophils and thymocytes.International immunology · 2024Article
- Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity.The Journal of clinical investigation · 2024Article
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- The versatile electric condition in mouse embryos for genome editing using a three-step square-wave pulse electroporator.Experimental animals · 2022Article
- Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo.Cell reports · 2021Article
- Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution.Nature metabolism · 2020Article
- Fibroblasts as a source of self-antigens for central immune tolerance.Nature immunology · 2020Article
- Chd4 choreographs self-antigen expression for central immune tolerance.Nature immunology · 2020Article
- CANT1 deficiency in a mouse model of Desbuquois dysplasia impairs glycosaminoglycan synthesis and chondrocyte differentiation in growth plate cartilage.FEBS open bio · 2020Article
- Deletion of the Tensin2 SH2-PTB domain, but not the loss of its PTPase activity, induces podocyte injury in FVB/N mouse strain.Experimental animals · 2020Article
- Development of a new monoclonal antibody specific to mouse Vγ6 chain.Life science alliance · 2019Article
- γδTCR-independent origin of neonatal γδ T cells prewired for IL-17 production.Current opinion in immunology · 2019Review
- T cell receptor signaling for γδT cell development.Inflammation and regeneration · 2019Review
- Interleukin-17-Producing γδ T Cells Originate from SOX13Immunity · 2018Article
- Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.PLoS biology · 2018Article
- Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.Scientific reports · 2018Article
- γδTCR recruits the Syk/PI3K axis to drive proinflammatory differentiation program.The Journal of clinical investigation · 2018Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thymus provides a specialized microenvironment in which distinct subsets of thymic epithelial cells (TECs) support T-cell development. Here, we describe the significance of cortical TECs (cTECs) in T-cell development, using a newly established mouse model of cTEC deficiency. The deficiency of mature cTECs caused a massive loss of thymic cellularity and impaired the development of αβT cells and invariant natural killer T cells. Unexpectedly, the differentiation of certain γδT-cell subpopulations-interleukin-17-producing Vγ4 and Vγ6 cells-was strongly dysregulated, resulting in the perturbation of γδT-mediated inflammatory responses in peripheral tissues. These findings show that cTECs contribute to the shaping of the TCR repertoire, not only of "conventional" αβT cells but also of inflammatory "innate" γδT cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.