Evidence map›Paper›PMID 25770082›Full record

Trial reportBrain, behavior, and immunity2015

Inflammation impairs social cognitive processing: A randomized controlled trial of endotoxin.

Mona Moieni, Michael R Irwin, Ivana Jevtic, Elizabeth C Breen, Naomi I Eisenberger

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain, behavior, and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01671150 (Inflammation-Induced Depressed Mood), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01671150 early_phase1completednot on this map

Inflammation-Induced Depressed Mood: The Role of Social Neurocognitive Mechanisms

TypeinterventionalSponsorUniversity of California, Los AngelesRan2011 to 2013Enrolled100ConditionsDepressionArmsendotoxin
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
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  7. Trial
  8. Review
  9. Article
  10. Article
  11. Somatovisceral influences on emotional development.Emotion review : journal of the International Society for Research on Emotion · 2023
    Article
  12. Article
  13. Review
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  15. Article
  16. Article
  17. Fevers and the social costs of acute infection in wild vervet monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mona MoieniDepartment of Psychology, University of California, Los Angeles, CA 90095-1563, United States.
Michael R IrwinSemel Institute for Neuroscience and Human Behavior, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095-7076, United States.
Ivana JevticDepartment of Psychology, University of California, Los Angeles, CA 90095-1563, United States.
Elizabeth C BreenSemel Institute for Neuroscience and Human Behavior, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095-7076, United States.
Naomi I EisenbergerDepartment of Psychology, University of California, Los Angeles, CA 90095-1563, United States. Electronic address: neisenbe@ucla.edu.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUBEN, DAVID B. · 2006 to 2017
$9.8M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Sleep, Inflamation, and Depression Occurrence in Breast Cancer SurvivorsR01CA160245 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2012 to 2016
$3.9M
Chronic Moderate Sleep Restriction in Older Long and Older Average SleepersR01HL095799 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI IRWIN, MICHAEL R, JEAN-LOUIS, GIRARDIN · 2011 to 2015
$3.8M
Mechanisms of Sleep Disruption HyperalgesiaR01DA032922 · NIDA · JOHNS HOPKINS UNIVERSITY · PI IRWIN, MICHAEL R, SMITH, MICHAEL T · 2012 to 2016
$2.7M
Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsR01CA119159 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2010
$2.2M
Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgR01AG034588 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2009 to 2013
$1.9M
Inflammation-Induced Depressed Mood: The Role of Social Neurocognitive MechanismsR01MH091352 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EISENBERGER, NAOMI ILANA · 2010 to 2013
$1.7M
Integrated Training in the Population, Behavioral, and Biomedical SciencesT32GM084903 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E · 2009 to 2013
$788k
Increasing Perceptions of Generativity in Lonely Older AdultsF31AG048668 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOIENI, MONA · 2014 to 2016
$102k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS R01 CA119159NCI NIH HHS R01CA119159NCI NIH HHS R01 CA160245NCI NIH HHS R01CA160245-01NHLBI NIH HHS R01 HL095799NHLBI NIH HHS R01HL095799NIA NIH HHS 1F31AG048668NIA NIH HHS F31 AG048668NIA NIH HHS P30 AG028748NIA NIH HHS P30AG028748NIA NIH HHS R01 AG026364NIA NIH HHS R01AG026364NIA NIH HHS R01 AG034588NIA NIH HHS R01AG034588NIDA NIH HHS R01 DA032922NIDA NIH HHS R01DA032922-01NIGMS NIH HHS 5T32GM084903NIGMS NIH HHS T32 GM084903NIMH NIH HHS 5R01MH091352NIMH NIH HHS R01 MH091352
6 · The paper itself

Abstract

unlabelledNeuropsychiatric disorders (e.g., autism, schizophrenia) are partially characterized by social cognitive deficits, including impairments in the ability to perceive others' emotional states, which is an aspect of social cognition known as theory of mind (ToM). There is also evidence that inflammation may be implicated in the etiology of these disorders, but experimental data linking inflammation to deficits in social cognition is sparse. Thus, we examined whether exposure to an experimental inflammatory challenge led to changes in ToM. One hundred and fifteen (n=115) healthy participants were randomly assigned to receive either endotoxin, which is an inflammatory challenge, or placebo. Participants completed a social cognition task, the Reading the Mind in the Eyes (RME) test, at baseline and at the peak of the inflammatory response for the endotoxin group. The RME test, a validated measure of ToM, evaluates how accurately participants can identify the emotional state of another person by looking only at their eyes. We found that endotoxin (vs. placebo) led to decreases in performance on the RME test from baseline to the peak of inflammatory response, indicating that acute inflammation can lead to decreases in the ability to accurately and reliably comprehend emotional information from others. Given that deficits in ToM are implicated in neuropsychiatric disorders, including those which may have an inflammatory basis, these results may have implications for understanding the links between inflammation, social cognition, and neuropsychiatric disorders. CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov NCT01671150.

Indexed as

Social PerceptionAdolescentAdultCognitionCytokinesEmotionsEndotoxinsFemaleHumansInflammationMaleNeuropsychological TestsTheory of MindYoung AdultCytokinesendotoxin, Escherichia coliEndotoxinsCytokinesEndotoxinInflammationMind in the EyesSocial cognitionTheory of mind

Identifiers

PMID25770082
PMCPMC4508216

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.