ArticleThe American journal of medicine2015
Apparent Treatment-resistant Hypertension Among Individuals with History of Stroke or Transient Ischemic Attack.
Article in The American journal of medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2018Guideline
- Physiologic profiling using plasma renin activity and aldosterone on blood pressure control among Ghanaian stroke survivors: A pilot trial.Equity neuroscience · 2025Article
- Prevalence and determinants of apparent treatment-resistant hypertension among patients in South African primary care: a single-centre observational study.BMC cardiovascular disorders · 2025Observational
- Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts.Journal of the American Heart Association · 2024Article
- Racial Disparities in Blood Pressure at Time of Acute Ischemic Stroke Presentation: A Population Study.Journal of the American Heart Association · 2024Article
- Resistant hypertension is associated with an increased cardiovascular risk compared to patients controlled on a similar multi-drug regimen.Journal of human hypertension · 2023Article
- Personalized hypertension treatment recommendations by a data-driven model.BMC medical informatics and decision making · 2023Article
- Promise of Physiological Profiling to Prevent Stroke in People of African Ancestry: Prototyping Ghana.Current neurology and neuroscience reports · 2022Review
- Apparent Treatment-Resistant Hypertension Among Stroke Survivors: A Transcontinental Study Assessing Impact of Race and Geography.American journal of hypertension · 2022Article
- Key determinants of long-term post-stroke mortality in Ghana.Journal of the neurological sciences · 2022Article
- Apparent Treatment Resistant Hypertension Among Stroke Survivors in Ghana.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Article
- Article
- Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study.Scientific reports · 2019Article
- Observational
- Article
- Psychosocial correlates of apparent treatment-resistant hypertension in the Jackson Heart Study.Journal of human hypertension · 2017Article
- Prevalence of electrocardiographic abnormalities based on hypertension severity and blood pressure levels: the Reasons for Geographic and Racial Differences in Stroke study.Journal of the American Society of Hypertension : JASH · 2016Article
- Is there an association between the prevalence of atrial fibrillation and severity and control of hypertension? The REasons for Geographic And Racial Differences in Stroke study.Journal of the American Society of Hypertension : JASH · 2016Article
- Obesity, African American Race, Chronic Kidney Disease, and Resistant Hypertension: The Step Beyond Observed Risk.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Brazilian Position Statement on Resistant Hypertension - 2020.Arquivos brasileiros de cardiologiaArticle
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Authors and funding
8 authors.
Funding
Abstract
backgroundBlood pressure control is a paramount goal in secondary stroke prevention; however, high prevalence of uncontrolled blood pressure and use of multiple antihypertensive medication classes in stroke patients suggest this goal is not being met. We determined the prevalence and factors associated with apparent treatment-resistant hypertension in persons with/without stroke or transient ischemic attack.
methodsData came from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, a national, population-based cohort of 30,239 black and white adults aged ≥45 years, enrolled 2003-2007, restricted to 11,719 participants with treated hypertension. Apparent treatment-resistant hypertension was defined as (1) uncontrolled blood pressure (systolic ≥140 mm Hg or diastolic ≥90 mm Hg) with ≥3 antihypertensive medication classes, or (2) use of ≥4 antihypertensive medication classes, regardless of blood pressure level. Poisson regression was used to calculate characteristics associated with apparent treatment-resistant hypertension.
resultsAmong hypertensive participants, prevalence of apparent treatment-resistant hypertension was 24.9% (422 of 1694) and 17.0% (1708 of 10,025) in individuals with and without history of stroke or transient ischemic attack, respectively. After adjustment for cardiovascular risk factors, the prevalence ratio for apparent treatment-resistant hypertension for those with versus without stroke or transient ischemic attack was 1.14 (95% confidence interval, 1.03-1.27). Among hypertensive participants with stroke or transient attack, male sex, black race, larger waist circumference, longer duration of hypertension, and reduced kidney function were associated with apparent treatment-resistant hypertension.
conclusionsThe high prevalence of apparent treatment-resistant hypertension among hypertensive persons with history of stroke or transient ischemic attack suggests the need for more individualized blood pressure monitoring and management.
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