Evidence map›Paper›PMID 25770011›Full record

ReviewExperimental cell research2015

Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy.

Jason Newton, Santiago Lima, Michael Maceyka, Sarah Spiegel

Abstract readReview
In one paragraph

Review in Experimental cell research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed.

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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jason NewtonDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, Virginia 23298, USA.
Santiago LimaDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, Virginia 23298, USA.
Michael MaceykaDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, Virginia 23298, USA.
Sarah SpiegelDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, Virginia 23298, USA. Electronic address: sspiegel@vcu.edu.

Funding

SPHINGOSINE AS A MODULATOR OF CELLULAR PROLIFERATIONR01GM043880 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SPIEGEL, SARAH · 1990 to 2023
$3.8M
Sphingosine Kinases in Cancer Cell SignalingR01CA061774 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SPIEGEL, SARAH · 1994 to 2015
$3.8M
Training In Functional Lipidomics In Cardiovascular & Respiratory DiseasesT32HL094290 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SPIEGEL, SARAH · 2009 to 2013
$1.2M
SphK1-TRAF2-cIAP interactions in NF-kB activation, colitis and associated cancerK22CA187314 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LIMA, SANTIAGO · 2014 to 2016
$446k
NCI NIH HHS 1K22CA187314NCI NIH HHS K22 CA187314NCI NIH HHS R01 CA061774NCI NIH HHS R01CA61774NHLBI NIH HHS 5T32HL094290NHLBI NIH HHS T32 HL094290NIGMS NIH HHS R01 GM043880NIGMS NIH HHS R01GM043880
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntineoplastic AgentsCell Transformation, NeoplasticCeramidesHumansLysophospholipidsMolecular Targeted TherapyNeoplasmsPhosphotransferases (Alcohol Group Acceptor)Receptors, LysophospholipidSignal TransductionSphingosineSphingosine KinaseAntineoplastic AgentsCeramidesLysophospholipidsPhosphotransferases (Alcohol Group Acceptor)Receptors, LysophospholipidSphingosinesphingosine 1-phosphateSphingosine KinaseCeramideSphingolipid rheostatSphingosine-1-phosphateSphingosine kinase

Identifiers

PMID25770011
PMCPMC4415605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.