ArticleApplied and environmental microbiology2015
In Vivo Transmission of an IncA/C Plasmid in Escherichia coli Depends on Tetracycline Concentration, and Acquisition of the Plasmid Results in a Variable Cost of Fitness.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Fitness costs and persistence of plasmid-mediated cephalosporin resistance inFrontiers in microbiology · 2026Review
- Broiler litter moisture and trace metals contribute to the persistence ofApplied and environmental microbiology · 2025Article
- Dynamic Spread of Antibiotic Resistance Determinants by Conjugation to a Human-Derived Gut Microbiota in a Transplanted Mouse Model.Antibiotics (Basel, Switzerland) · 2025Article
- An antiplasmid system drives antibiotic resistance gene integration in carbapenemase-producing Escherichia coli lineages.Nature communications · 2024Article
- Dissemination of IncI plasmid encodingAntimicrobial agents and chemotherapy · 2023Article
- Multidrug resistance plasmids underlie clonal expansions and international spread of Salmonella enterica serotype 1,4,[5],12:i:- ST34 in Southeast Asia.Communications biology · 2023Article
- Characterisation and mobilisation of IncA/C plasmid-mediated antibiotic resistance in Edwardsiella ictaluri.Journal of global antimicrobial resistance · 2023Article
- The Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine, a Complex Phenomenon: A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- Incompatibility Group I1 (IncI1) Plasmids: Their Genetics, Biology, and Public Health Relevance.Microbiology and molecular biology reviews : MMBR · 2021Review
- Antimicrobial Resistance Hidden within MultiserovarAntimicrobial agents and chemotherapy · 2021Article
- Genomic Insights into a Colistin-Resistant UropathogenicMicroorganisms · 2021Article
- Role of Plasmids in the Ecology and Evolution of "High-Risk" Extraintestinal PathogenicEcoSal Plus · 2021Review
- Temperature-Regulated IncX3 Plasmid Characteristics and the Role of Plasmid-Encoded H-NS in Thermoregulation.Frontiers in microbiology · 2021Article
- Article
- Advantage of the F2:A1:B- IncF Pandemic Plasmid over IncC Plasmids inAntimicrobial agents and chemotherapy · 2019Article
- Sex pilus specific bacteriophage to drive bacterial population towards antibiotic sensitivity.Scientific reports · 2019Article
- Evaluation of Incompatibility Group I1 (IncI1) Plasmid-ContainingFrontiers in veterinary science · 2019Article
- Conjugation-Mediated Horizontal Gene Transfer of Clostridium perfringens Plasmids in the Chicken Gastrointestinal Tract Results in the Formation of New Virulent Strains.Applied and environmental microbiology · 2017Article
- The use of minimum selectable concentrations (MSCs) for determining the selection of antimicrobial resistant bacteria.Ecotoxicology (London, England) · 2017Article
- Polyclonal Intestinal Colonization with Extended-Spectrum Cephalosporin-Resistant Enterobacteriaceae upon Traveling to India.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IncA/C plasmids are broad-host-range plasmids enabling multidrug resistance that have emerged worldwide among bacterial pathogens of humans and animals. Although antibiotic usage is suspected to be a driving force in the emergence of such strains, few studies have examined the impact of different types of antibiotic administration on the selection of plasmid-containing multidrug resistant isolates. In this study, chlortetracycline treatment at different concentrations in pig feed was examined for its impact on selection and dissemination of an IncA/C plasmid introduced orally via a commensal Escherichia coli host. Continuous low-dose administration of chlortetracycline at 50 g per ton had no observable impact on the proportions of IncA/C plasmid-containing E. coli from pig feces over the course of 35 days. In contrast, high-dose administration of chlortetracycline at 350 g per ton significantly increased IncA/C plasmid-containing E. coli in pig feces (P < 0.001) and increased movement of the IncA/C plasmid to other indigenous E. coli hosts. There was no evidence of conjugal transfer of the IncA/C plasmid to bacterial species other than E. coli. In vitro competition assays demonstrated that bacterial host background substantially impacted the cost of IncA/C plasmid carriage in E. coli and Salmonella. In vitro transfer and selection experiments demonstrated that tetracycline at 32 μg/ml was necessary to enhance IncA/C plasmid conjugative transfer, while subinhibitory concentrations of tetracycline in vitro strongly selected for IncA/C plasmid-containing E. coli. Together, these experiments improve our knowledge on the impact of differing concentrations of tetracycline on the selection of IncA/C-type plasmids.
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