Evidence map›Paper›PMID 25769542›Full record

Trial reportHaematologica2015

Expression profiling of adult acute lymphoblastic leukemia identifies a BCR-ABL1-like subgroup characterized by high non-response and relapse rates.

Judith M Boer, Jasper E Koenders, Bronno van der Holt, Carla Exalto, Mathijs A Sanders, Jan J Cornelissen, Peter J M Valk, Monique L den Boer, Anita W Rijneveld

Abstract readClinical TrialLetter
In one paragraph

Trial report in Haematologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Has Ph-like ALL Superseded Ph+ ALL as the Least Favorable Subtype?Best practice & research. Clinical haematology · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Judith M BoerLaboratory of Pediatric Oncology/Hematology, Erasmus MC -Sophia Children's Hospital, Rotterdam, the Netherlands.
Jasper E KoendersDepartment of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
Bronno van der HoltHOVON Data Center, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
Carla ExaltoDepartment of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
Mathijs A SandersDepartment of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
Jan J CornelissenDepartment of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
Peter J M ValkDepartment of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
Monique L den BoerLaboratory of Pediatric Oncology/Hematology, Erasmus MC -Sophia Children's Hospital, Rotterdam, the Netherlands m.l.denboer@erasmusmc.nl a.rijneveld@erasmusmc.nl.
Anita W RijneveldDepartment of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands m.l.denboer@erasmusmc.nl a.rijneveld@erasmusmc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hematopoietic Stem Cell TransplantationAdolescentAdultAgedAntineoplastic AgentsFusion Proteins, bcr-ablGene ExpressionGene Expression ProfilingHistone-Lysine N-MethyltransferaseHumansIkaros Transcription FactorImatinib MesylateMiddle AgedMutationMyeloid-Lymphoid Leukemia ProteinPrecursor Cell Lymphoblastic Leukemia-LymphomaAntineoplastic AgentsBCR-ABL1 fusion protein, humanFusion Proteins, bcr-ablHistone-Lysine N-MethyltransferaseIkaros Transcription FactorIKZF1 protein, humanImatinib MesylateKMT2A protein, humanMyeloid-Lymphoid Leukemia ProteinProtein Kinase InhibitorsB-cell precursor acute lymphoblastic leukemiaBCR-ABL-like acute lymphoblastic leukemiaexpression profilingoutcome

Identifiers

PMID25769542
PMCPMC4486237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.