Evidence map›Paper›PMID 25769412›Full record

Trial reportClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2015

Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial.

Karen A Frankwich, Jeremy Egnatios, Mandy L Kenyon, Thomas R Rutledge, Patricia S Liao, Samir Gupta, Karen L Herbst, Amir Zarrinpar

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01859403 (Nutrigenomics), which is not on this map. Cited by 23 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01859403 nacompletednot on this map

Nutrigenomics: Personalizing Weight Loss for Obese Veterans

TypeinterventionalSponsorUniversity of California, San DiegoRan2012 to 2014Enrolled51ConditionsObesityArmsPersonalized Genomics, Usual Care
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Are There Any Effective Behavior Change Strategies for Communicating Genetic Risk in Obesity Prevention and Body Weight Reduction Interventions?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  17. Precision Medicine for Obesity.Digestive disease interventions · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Karen A Frankwich *Division of Endocrinology, University of California, San Diego.
Jeremy Egnatios *School of Medicine, University of California, San Diego.
Mandy L KenyonVA San Diego Health System, La Jolla, CA.
Thomas R RutledgeVA San Diego Health System, La Jolla, CA.
Patricia S LiaoDivision of Endocrinology, University of California, San Diego.
Samir GuptaVA San Diego Health System, La Jolla, CA.
Karen L HerbstDivision of Endocrinology, University of California, San Diego.
Amir ZarrinparVA San Diego Health System, La Jolla, CA.
University of California, San Diego · USUC San Diego Health System · US

Funding

SYNTHETIC SYSTEMSP50GM085764 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2010 to 2018
$23.3M
Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
The UCSD Digestive Diseases Research Development CenterR24DK080506 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ECKMANN, LARS · 2008 to 2012
$2.7M
Research Training Program in Geriatric Neuropsychiatry for Medical StudentsR25MH071544 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JESTE, DILIP V. · 2004 to 2013
$2.5M
San Diego Clinical and Translational Research InstituteKL2TR000099 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2014
$1.1M
NCATS NIH HHS KL2 TR000099NCATS NIH HHS KL2 TR00099NIDDK NIH HHS R24 DK080506NIDDK NIH HHS T32 DK007202NIGMS NIH HHS P50 GM085764NIMH NIH HHS R25 MH071544NIMH NIH HHS R25 MH71544
6 · The paper itself

Abstract

BACKGROUND &

aimsMany companies provide genetic tests for obesity-related polymorphisms (nutrigenetics) and make dietary recommendations for weight loss that are based on the results. We performed a randomized controlled trial to determine whether more participants who followed a nutrigenetic-guided diet lost ≥5% of their body weight than participants on a standard balanced diet for 8 and 24 weeks.

methodsWe performed a prospective study of 51 obese or overweight U.S. veterans on an established weight management program at the Veterans Administration San Diego Healthcare System (the MOVE! program). Participants were randomly assigned to groups placed on a nutrigenetic-guided diet (balanced, low-carbohydrate, low-fat, or Mediterranean; n = 30) or a standard balanced diet (n = 21). Nutrigenetic diets were selected on the basis of results from the Pathway FIT test.

resultsThere was no significant difference in the percentage of participants on the balanced diet vs the nutrigenetic-guided diet who lost 5% of their body weight at 8 weeks (35.0% ± 20.9% vs 26.9% ± 17.1%, respectively; P = .28) or at 24 weeks. Both groups had difficulty adhering to the diets. However, adherence to the nutrigenetic-guided diet correlated with weight loss (r = 0.74; P = 4.0 × 10(-5)), but not adherence to standard therapy (r = 0.34; P = .23). Participants who had low-risk polymorphisms for obesity lost more weight than all other participants at 8 weeks (5.0% vs 2.9%, respectively; P = .02) and had significantly greater reductions in body mass index (6.4% vs 3.6%, respectively; P = .03) and waist circumference (6.5% vs 2.6%, respectively; P = .02) at 24 weeks.

conclusionsIn a prospective study, a nutrigenetic-based diet did not increase weight loss compared with a standard balanced diet. However, genetic features can identify individuals most likely to benefit from a balanced diet weight loss strategy; these findings require further investigation. ClinicalTrials.gov number: NCT01859403.

Indexed as

Weight LossDietFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeUnited StatesVeteransBMIDietNutrigenomicsPersonalized Medicine

Identifiers

PMID25769412
PMCPMC4546861
OpenAlexW2141214563

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.