ArticleJournal of neuroscience methods2015
An automated behavioral box to assess forelimb function in rats.
Article in Journal of neuroscience methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- A paradigm for skilled forelimb reaching by head-restrained mice.bioRxiv : the preprint server for biology · 2026Article
- Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered after stroke.Journal of neuroinflammation · 2025Article
- Effective cerebellar neuroprosthetic control after stroke.Cell reports · 2025Article
- Coupling of Slow Oscillations in the Prefrontal and Motor Cortex Predicts Onset of Spindle Trains and Persistent Memory Reactivations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Skilled reaching test for shoulder function assessment in a rat model of rotator cuff tear: a pilot study.BMC musculoskeletal disorders · 2024Article
- Information flow between motor cortex and striatum reverses during skill learning.Current biology : CB · 2024Article
- Emergence of task-related spatiotemporal population dynamics in transplanted neurons.Nature communications · 2023Article
- AutoRG: An automatized reach-to-grasp platform technology for assessing forelimb motor function, neural circuit activation, and cognition in rodents.Journal of neuroscience methods · 2023Article
- Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning.eNeuro · 2023Article
- Improved Behavioral Box and Sensing Techniques for Analysis of Tactile Discrimination Tasks in Rodents.Sensors (Basel, Switzerland) · 2022Article
- Transition from predictable to variable motor cortex and striatal ensemble patterning during behavioral exploration.Nature communications · 2022Article
- Recovery of consolidation after sleep following stroke-interaction of slow waves, spindles, and GABA.Cell reports · 2022Article
- Coupling between motor cortex and striatum increases during sleep over long-term skill learning.eLife · 2021Article
- Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke.Cell reports · 2021Article
- Single-trial cross-area neural population dynamics during long-term skill learning.Nature communications · 2020Article
- Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories.Journal of visualized experiments : JoVE · 2019Article
- Automated Forelimb Tasks for Rodents: Current Advantages and Limitations, and Future Promise.Neurorehabilitation and neural repair · 2019Article
- Emergent modular neural control drives coordinated motor actions.Nature neuroscience · 2019Article
- Chronic stability of single-channel neurophysiological correlates of gross and fine reaching movements in the rat.PloS one · 2019Article
- Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke.Nature medicine · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRodent forelimb reaching behaviors are commonly assessed using a single-pellet reach-to-grasp task. While the task is widely recognized as a very sensitive measure of distal limb function, it is also known to be very labor-intensive, both for initial training and the daily assessment of function. NEW
methodUsing components developed by open-source electronics platforms, we have designed and tested a low-cost automated behavioral box to measure forelimb function in rats. Our apparatus, made primarily of acrylic, was equipped with multiple sensors to control the duration and difficulty of the task, detect reach outcomes, and dispense pellets. Our control software, developed in MATLAB, was also used to control a camera in order to capture and process video during reaches. Importantly, such processing could monitor task performance in near real-time.
resultsWe further demonstrate that the automated apparatus can be used to expedite skill acquisition, thereby increasing throughput as well as facilitating studies of early versus late motor learning. The setup is also readily compatible with chronic electrophysiological monitoring. COMPARISON WITH EXISTING
methodsCompared to a previous version of this task, our setup provides a more efficient method to train and test rodents for studies of motor learning and recovery of function after stroke. The unbiased delivery of behavioral cues and outcomes also facilitates electrophysiological studies.
conclusionsIn summary, our automated behavioral box will allow high-throughput and efficient monitoring of rat forelimb function in both healthy and injured animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.