ArticleBrain and cognition2015
Response inhibition and response monitoring in a saccadic double-step task in schizophrenia.
Article in Brain and cognition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Trial
- Associations between smooth pursuit, predictive pursuit, anomalous self-experiences, and psychotic-like experiences.European archives of psychiatry and clinical neuroscience · 2026Article
- Article
- Peripheral Complement Factor-Based Biomarkers for Patients with First-Episode Schizophrenia.Neuropsychiatric disease and treatment · 2023Article
- Altered Effective Connectivity within an Oculomotor Control Network in Unaffected Relatives of Individuals with Schizophrenia.Brain sciences · 2021Article
- Inhibitory Top-Down Control Deficits in Schizophrenia With Auditory Verbal Hallucinations: A Go/NoGo Task.Frontiers in psychiatry · 2021Article
- Altered effective connectivity within an oculomotor control network in individuals with schizophrenia.NeuroImage. Clinical · 2021Article
- Abnormal neural functions associated with motor inhibition deficits in schizophrenia and bipolar disorder.Human brain mapping · 2019Article
- A review of visual aftereffects in schizophrenia.Neuroscience and biobehavioral reviews · 2019Review
- Disconnected and Hyperactive: A Replication of Sensorimotor Cortex Abnormalities in Patients With Schizophrenia During Proactive Response Inhibition.Schizophrenia bulletin · 2019Article
- Reduced pupil dilation during action preparation in schizophrenia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2018Article
- Transsaccadic Perception Deficits in Schizophrenia Reflect the Improper Internal Monitoring of Eye Movement Rather Than Abnormal Sensory Processing.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Sensory and cross-network contributions to response inhibition in patients with schizophrenia.NeuroImage. Clinical · 2018Article
- A novel continuous inhibitory-control task: variation in individual performance by young pheasants (Phasianus colchicus).Animal cognition · 2017Article
- Towards a unifying mechanism for cancelling movements.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Speed of saccade execution and inhibition associated with fractional anisotropy in distinct fronto-frontal and fronto-striatal white matter pathways.Human brain mapping · 2016Article
- Sex dependency of inhibitory control functions.Biology of sex differences · 2016Article
- Ultrafast initiation of a neural race by impending errors.The Journal of physiology · 2015Article
- Disrupted Saccadic Corollary Discharge in Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCognitive control impairments are linked to functional outcome in schizophrenia. The goal of the current study was to investigate precise abnormalities in two aspects of cognitive control: reactively changing a prepared response, and monitoring performance and adjusting behavior accordingly. We adapted an oculomotor task from neurophysiological studies of the cellular basis of cognitive control in nonhuman primates.
methods16 medicated outpatients with schizophrenia (SZ) and 18 demographically-matched healthy controls performed the modified double-step task. In this task, participants were required to make a saccade to a visual target. Infrequently, the target jumped to a new location and participants were instructed to rapidly inhibit and change their response. A race model provided an estimate of the time needed to cancel a planned movement. Response monitoring was assessed by measuring reaction time (RT) adjustments based on trial history.
resultsSZ patients had normal visually-guided saccadic RTs but required more time to switch the response to the new target location. Additionally, the estimated latency of inhibition was longer in patients and related to employment. Finally, although both groups slowed down on trials that required inhibiting and changing a response, patients showed exaggerated performance-based adjustments in RTs, which was correlated with positive symptom severity.
conclusionsSZ patients have impairments in rapidly inhibiting eye movements and show idiosyncratic response monitoring. These results are consistent with functional abnormalities in a network involving cortical oculomotor regions, the superior colliculus, and basal ganglia, as described in neurophysiological studies of non-human primates using an identical paradigm, and provide a translational bridge for understanding cognitive symptoms of SZ.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.