ArticleNutrients2015
Changes in composition of caecal microbiota associated with increased colon inflammation in interleukin-10 gene-deficient mice inoculated with Enterococcus species.
Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics study.The World Allergy Organization journal · 2025Article
- Phylogenetic Biodiversity Metrics Should Account for Both Accumulation and Attrition of Evolutionary Heritage.Systematic biology · 2024Article
- Effects of repeated intragastric administrations with heat-inactivatedFrontiers in neuroscience · 2024Article
- Fermented Chinese Herbs Improve the Growth and Immunity of Growing Pigs through Regulating Colon Microbiota and Metabolites.Animals : an open access journal from MDPI · 2023Article
- Changes in Oral Microbial Diversity in a Piglet Model of Traumatic Brain Injury.Brain sciences · 2022Article
- Nutrigenomics and Nutrigenetics Research in New Zealand, and Its Relevance and Application to Gastrointestinal Health.Nutrients · 2022Review
- Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder.Scientific reports · 2022Observational
- Effect of urolithin A on the improvement of vascular endothelial function depends on the gut microbiota.Frontiers in nutrition · 2022Article
- The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine.Applied microbiology and biotechnology · 2021Article
- Gut microorganisms and their metabolites modulate the severity of acute colitis in a tryptophan metabolism-dependent manner.European journal of nutrition · 2020Article
- Altered gut microbiota correlated with systemic inflammation in children with Kawasaki disease.Scientific reports · 2020Article
- Association of Hyperuricemia With Immune Disorders and Intestinal Barrier Dysfunction.Frontiers in physiology · 2020Article
- Segmental differences in ion transport in rat cecum.Pflugers Archiv : European journal of physiology · 2019Article
- Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation.The American journal of pathology · 2018Article
- Heme Oxygenase-1 as a Modulator of Intestinal Inflammation Development and Progression.Frontiers in immunology · 2018Review
- Immunomodulation and effects on microbiota after in ovo administration of chicken cathelicidin-2.PloS one · 2018Article
- Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome.Microbiome · 2017Article
- Dahuang Zexie Decoction Protects against High-Fat Diet-Induced NAFLD by Modulating Gut Microbiota-Mediated Toll-Like Receptor 4 Signaling Activation and Loss of Intestinal Barrier.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Sodium Butyrate Reduces Colitogenic Immunoglobulin A-Coated Bacteria and Modifies the Composition of Microbiota in IL-10 Deficient Mice.Nutrients · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human inflammatory bowel disease (IBD) is a chronic intestinal disease where the resident microbiota contributes to disease development, yet the specific mechanisms remain unclear. Interleukin-10 gene-deficient (Il10-/-) mice develop inflammation similar to IBD, due in part to an inappropriate response to commensal bacteria. We have previously reported changes in intestinal morphology and colonic gene expression in Il10-/- mice in response to oral bacterial inoculation. In this study, we aimed to identify specific changes in the caecal microbiota associated with colonic inflammation in these mice. The microbiota was evaluated using pyrotag sequencing, denaturing gradient gel electrophoresis (DGGE) and quantitative real-time PCR. Microbiota profiles were influenced by genotype of the mice and by bacterial inoculation, and a strong correlation was observed between the microbiota and colonic inflammation scores. Although un-inoculated Il10-/- and C57 mice had similar microbiota communities, bacterial inoculation resulted in different changes to the microbiota in Il10-/- and C57 mice. Inoculated Il10-/- mice had significantly less total bacteria than un-inoculated Il10-/- mice, with a strong negative correlation between total bacterial numbers, relative abundance of Escherichia/Shigella, microbiota diversity, and colonic inflammation score. Our results show a putative causative role for the microbiota in the development of IBD, with potentially key roles for Akkermansia, or for Bacteroides, Helicobacter, Parabacteroides, and Alistipes, depending on the composition of the bacterial inoculum. These data support the use of bacterially-inoculated Il10-/- mice as an appropriate model to investigate human IBD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.