ArticlePloS one2015
p38 MAPK signaling in postnatal tendon growth and remodeling.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Overload in a Rat In Vivo Model of Synergist Ablation Induces Tendon Multiscale Structural and Functional Degeneration.Journal of biomechanical engineering · 2023Article
- Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors.Cell and tissue research · 2023Article
- Article
- Exosomes from tendon derived stem cells promote tendon repair through miR-144-3p-regulated tenocyte proliferation and migration.Stem cell research & therapy · 2022Article
- The Impact of Hyaluronic Acid on Tendon Physiology and Its Clinical Application in Tendinopathies.Cells · 2021Review
- Tendinopathy.Nature reviews. Disease primers · 2021Review
- Human Tendon Stem/Progenitor Cell Features and Functionality Are Highly Influenced byFrontiers in bioengineering and biotechnology · 2021Article
- Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons.American journal of physiology. Cell physiology · 2020Article
- Scleraxis is required for the growth of adult tendons in response to mechanical loading.JCI insight · 2020Article
- Recent advances in tendinopathy.Faculty reviews · 2020Review
- Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Insulin-like growth factor 1 signaling in tenocytes is required for adult tendon growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- The impact of loading, unloading, ageing and injury on the human tendon.The Journal of physiology · 2019Review
- Comparative multi-scale hierarchical structure of the tail, plantaris, and Achilles tendons in the rat.Journal of anatomy · 2019Article
- The roles of inflammatory mediators and immunocytes in tendinopathy.Journal of orthopaedic translation · 2018Review
- Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling.American journal of physiology. Cell physiology · 2018Article
- Growth differentiation factor‑5 induces tenomodulin expression via phosphorylation of p38 and promotes viability of murine mesenchymal stem cells from compact bone.Molecular medicine reports · 2018Article
- Pathogenesis and Management of Tendinopathies in Sports Medicine.Translational sports medicine · 2018Article
- Sex differences in tendon structure and function.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Tendon is a dynamic tissue whose structure and function is influenced by mechanical loading, but little is known about the fundamental mechanisms that regulate tendon growth and remodeling in vivo. Data from cultured tendon fibroblasts indicated that the p38 MAPK pathway plays an important role in tendon fibroblast proliferation and collagen synthesis in vitro. To gain greater insight into the mechanisms of tendon growth, and explore the role of p38 MAPK signaling in this process, we tested the hypotheses that inducing plantaris tendon growth through the ablation of the synergist Achilles tendon would result in rapid expansion of a neotendon matrix surrounding the original tendon, and that treatment with the p38 MAPK inhibitor SB203580 would prevent this growth. Rats were treated with vehicle or SB203580, and subjected to synergist ablation by bilateral tenectomy of the Achilles tendon. Changes in histological and biochemical properties of plantaris tendons were analyzed 3, 7, or 28 days after overload, and comparisons were made to non-overloaded animals. By 28 days after overload, tendon mass had increased by 30% compared to non-overloaded samples, and cross-sectional area (CSA) increased by around 50%, with most of the change occurring in the neotendon. The expansion in CSA initially occurred through the synthesis of a hyaluronic acid rich matrix that was progressively replaced with mature collagen. Pericytes were present in areas of active tendon growth, but never in the original tendon ECM. Inhibition of p38 MAPK resulted in a profound decrease in IL6 expression, and had a modest effect on the expression of other ECM and cell proliferation genes, but had a negligible impact on overall tendon growth. The combined results from this study provided novel insights into tendon mechanobiology, and suggest that p38 MAPK signaling does not appear to be necessary for tendon growth in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.