Observational studyAIDS (London, England)2015
Time above 1500 copies: a viral load measure for assessing transmission risk of HIV-positive patients in care.
Observational study in AIDS (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review on cumulative HIV viraemia among people living with HIV receiving antiretroviral treatment and its association with mortality and morbidity.International health · 2024Pooled it
- Integrated Population Pharmacokinetic-pharmacodynamic Modeling of HIV Virus-host Infection Dynamics in Patients Undergoing Antiretroviral Monotherapy.The AAPS journal · 2025Article
- Acceptability and Feasibility of Self-Collected Dried Blood Spot Specimens for Viral Load Monitoring among Rural Older People Living with HIV.AIDS and behavior · 2025Article
- Viral load change and time to death among adult HIV/AIDS patients on ART after test-and-treat in Northwest Ethiopia: a retrospective multi-center follow-up study using Bayesian joint modeling.Frontiers in public health · 2025Article
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- Person-time spent with HIV viral load above 1500 copies/mL among Miami-Dade County Ryan White Program clients, 2017-2019: a retrospective analysis.Annals of epidemiology · 2023Article
- Digital directly observed therapy to monitor adherence to medications: a scoping review.HIV research & clinical practice · 2022Article
- The Impact of Churn on HIV Outcomes in a Southern United States Clinical Cohort.Open forum infectious diseases · 2022Article
- Identifying Geographic Areas of Washington, DC, With Increased Potential for Sexual HIV Transmission Among People With HIV With STIs and Concurrent Elevated HIV RNA: Data From the DC Cohort.Open forum infectious diseases · 2022Article
- Longitudinal analysis of HIV outcomes for persons living with HIV in non-urban areas in southern Alberta, Canada.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2022Article
- HIV-serodifferent couples' perspectives and practices regarding HIV prevention strategies: A mixed methods study.PLOS global public health · 2022Article
- A public health approach to monitoring HIV with resistance to HIV pre-exposure prophylaxis.PloS one · 2022Article
- Article
- A Semi-Quantitative Isothermal Diagnostic Assay Utilizing Competitive Amplification.Analytical chemistry · 2021Article
- HIV-1 Transmission linkages among persons with incident infection to inform public health surveillance.EClinicalMedicine · 2021Article
- Identifying patterns of retention in care and viral suppression using latent class analysis among women living with HIV in Florida 2015-2017.AIDS care · 2021Article
- ATR-FTIR spectroscopy in blood plasma combined with multivariate analysis to detect HIV infection in pregnant women.Scientific reports · 2020Article
- Machine Learning Analysis Reveals Novel Neuroimaging and Clinical Signatures of Frailty in HIV.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- The HIV Continuum of Care for Adolescents and Young Adults Attending 13 Urban US HIV Care Centers of the NICHD-ATN-CDC-HRSA SMILE Collaborative.Journal of acquired immune deficiency syndromes (1999) · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveWe examined HIV transmission potential of patients in care by analyzing the amount of person-time spent above a viral load threshold that increases risk for transmission.
designObservational cohort and supplemental data.
methodsThe cohort included HIV patients who received care at six HIV clinics in the United States, from 1 April 2009 to 31 March 2013, and had two or more viral load tests during this interval. Person-time (in days) above a viral load of 1500 copies/ml out of the total observation time was determined by inspecting consecutive pairs of viral load results and the time intervals between those pairs. The person-time rate ratios comparing demographic and clinical subgroups were estimated with Poisson regression.
resultsThe cohort included 14 532 patients observed for a median of 1073 days with a median of nine viral load records. Ninety percent of the patients had been prescribed antiretroviral therapy. On average, viral load exceeded 1500 copies/ml during 23% of the patients' observation time (average of 84 days per year, per patient). Percentage of person-time above the threshold was higher among patients who had more than a fourth of their viral load pairs exceeding a 6-month interval (34% of observation time), patients not on antiretroviral therapy (58% of time), new/re-engaging patients (34% of time), patients 16-39 years of age (32% of time), and patients of black race (26% of time).
conclusionHIV patients in care spent an average of nearly a quarter of their time with viral loads above 1500 copies/ml, higher among some subgroups, placing them at risk for potentially transmitting HIV to others.
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