ArticlePLoS genetics2015
The role of China in the global spread of the current cholera pandemic.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed.
- DiagnoDating: diagnostics for dated phylogenies in microbial population genetics.Molecular biology and evolution · 2026Article
- Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss.Nature ecology & evolution · 2026Article
- Inference of Multiple Mergers while Dating a Pathogen Phylogeny.Systematic biology · 2025Article
- Revisiting the Genomic Epidemiology of Distinct Phage-TypeMicroorganisms · 2025Article
- Bayesian Inference of Pathogen Phylogeography using the Structured Coalescent Model.PLoS computational biology · 2025Article
- Inflammation induced by the new lineage ofFrontiers in immunology · 2025Article
- Prevalence ofInternational journal of microbiology · 2025Article
- Genomic evidence of two-staged transmission of the early seventh cholera pandemic.Nature communications · 2024Article
- Evolutionary dynamics of the successful expansion of pandemic Vibrio parahaemolyticus ST3 in Latin America.Nature communications · 2024Article
- Congruity of genomic and epidemiological data in modelling of local cholera outbreaks.Proceedings. Biological sciences · 2024Article
- Genomic epidemiology of Vibrio cholerae during a mass vaccination campaign of displaced communities in Bangladesh.Nature communications · 2023Article
- Spatiotemporal and Seasonal Trends of Class A and B Notifiable Infectious Diseases in China: Retrospective Analysis.JMIR public health and surveillance · 2023Article
- Genomic and Evolutionary Insights into Australian Toxigenic Vibrio cholerae O1 Strains.Microbiology spectrum · 2023Article
- Application of a core genome sequence typing (cgMLST) pipeline for surveillance ofFrontiers in cellular and infection microbiology · 2023Article
- A scalable analytical approach from bacterial genomes to epidemiology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Inhibition of bacterial FMN transferase: A potential avenue for countering antimicrobial resistance.Protein science : a publication of the Protein Society · 2022Article
- Systematic review and meta-analysis of environmentalHeliyon · 2022Review
- Cholera Caused by a New Clone of Serogroup O1China CDC weekly · 2022Article
- Molecular characterization ofJournal of medical microbiology · 2021Article
- A Combination of Metagenomic and Cultivation Approaches Reveals Hypermutator Phenotypes within Vibrio cholerae-Infected Patients.mSystems · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Epidemics and pandemics of cholera, a severe diarrheal disease, have occurred since the early 19th century and waves of epidemic disease continue today. Cholera epidemics are caused by individual, genetically monomorphic lineages of Vibrio cholerae: the ongoing seventh pandemic, which has spread globally since 1961, is associated with lineage L2 of biotype El Tor. Previous genomic studies of the epidemiology of the seventh pandemic identified three successive sub-lineages within L2, designated waves 1 to 3, which spread globally from the Bay of Bengal on multiple occasions. However, these studies did not include samples from China, which also experienced multiple epidemics of cholera in recent decades. We sequenced the genomes of 71 strains isolated in China between 1961 and 2010, as well as eight from other sources, and compared them with 181 published genomes. The results indicated that outbreaks in China between 1960 and 1990 were associated with wave 1 whereas later outbreaks were associated with wave 2. However, the previously defined waves overlapped temporally, and are an inadequate representation of the shape of the global genealogy. We therefore suggest replacing them by a series of tightly delineated clades. Between 1960 and 1990 multiple such clades were imported into China, underwent further microevolution there and then spread to other countries. China was thus both a sink and source during the pandemic spread of V. cholerae, and needs to be included in reconstructions of the global patterns of spread of cholera.
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