Evidence map›Paper›PMID 25768440›Full record

ArticlePloS one2015

Predictive parameters of arteriovenous fistula functional maturation in a population of patients with end-stage renal disease.

Khalid Bashar, Adeel Zafar, Sawsan Elsheikh, Donagh A Healy, Mary Clarke-Moloney, Liam Casserly, Paul E Burke, Eamon G Kavanagh, Stewart R Walsh

Registry-linked trialAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03188978 (High-intensity Atorvastatin for Arteriovenous Fistula Failure), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03188978 phase1 / phase2withdrawnnot on this mapstarted 2018, after this paper: background citation

High-intensity Atorvastatin for Arteriovenous Fistula Failure (HAFF): A Feasibility Pilot Study

TypeinterventionalSponsorAlbany Medical CollegeRan2018 to 2019Enrolled0ConditionsPrimary Arteriovenous Fistula FailureArmsAtorvastatin 40mg, Placebo
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  14. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model.American journal of physiology. Heart and circulatory physiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Khalid BasharDepartment of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.
Adeel ZafarDepartment of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.
Sawsan ElsheikhDepartment of Acute Medicine, James Connolly Memorial Hospital, Dublin, Ireland.
Donagh A HealyDepartment of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.
Mary Clarke-MoloneyDepartment of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.
Liam CasserlyDepartment of Nephrology, University Hospital Limerick, Limerick, Ireland.
Paul E BurkeDepartment of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.
Eamon G KavanaghDepartment of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.
Stewart R WalshDepartment of Surgery, National University of Ireland, Galway, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWith increasing numbers of patients diagnosed with ESRD, arteriovenous fistula (AVF) maturation has become a major factor in improving both dialysis related outcomes and quality of life of those patients. Compared to other types of access it has been established that a functional AVF access is the least likely to be associated with thrombosis, infection, hospital admissions, secondary interventions to maintain patency and death.

aimStudy of demographic factors implicated in the functional maturation of arteriovenous fistulas. Also, to explore any possible association between preoperative haematological investigations and functional maturation.

methodsWe performed a retrospective chart review of all patients with ESRD who were referred to the vascular service in the University Hospital of Limerick for creation of vascular access for HD. We included patients with primary AVFs; and excluded those who underwent secondary procedures.

resultsOverall AVF functional maturation rate in our study was 53.7% (52/97). Female gender showed significant association with nonmaturation (P = 0.004) and was the only predictor for non-maturation in a logistic regression model (P = 0.011). Patients who had history of renal transplant (P = 0.036), had relatively lower haemoglobin levels (P = 0.01) and were on calcium channel blockers (P = 0.001) showed better functional maturation rates.

conclusionFemale gender was found to be associated with functional non-maturation, while a history kidney transplant, calcium channel-blocker agents and low haemoglobin levels were all associated with successful functional maturation. In view of the conflicting evidence in the literature, large prospective multi-centre registry-based studies with well-defined outcomes are needed.

Indexed as

ArteriesVeinsAgedBiomarkersComorbidityFemaleHematologic TestsHumansKidney Failure, ChronicMalePrognosisRenal DialysisRetrospective StudiesBiomarkers

Identifiers

PMID25768440
PMCPMC4358953

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.