ArticleOptics letters2015
Assessing microstructures of the cornea with Gabor-domain optical coherence microscopy: pathway for corneal physiology and diseases.
Article in Optics letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- In vivo, contactless, cellular resolution imaging of the human cornea with Powell lens based line field OCT.Scientific reports · 2024Article
- Cellular structural and functional imaging of donor and pathological corneas with label-free dual-mode full-field optical coherence tomography.Biomedical optics express · 2024Article
- Non-invasiveBiomedical optics express · 2023Article
- Line-scanning SD-OCT forBiomedical optics express · 2022Article
- Unbiased corneal tissue analysis using Gabor-domain optical coherence microscopy and machine learning for automatic segmentation of corneal endothelial cells.Journal of biomedical optics · 2020Article
- Normative values of the retinal macular thickness in a middle eastern population.BMC ophthalmology · 2020Article
- Article
- Quantitative assessment of human donor corneal endothelium with Gabor domain optical coherence microscopy.Journal of biomedical optics · 2019Article
- Capabilities of Gabor-domain optical coherence microscopy for the assessment of corneal disease.Journal of biomedical optics · 2019Article
- 250 kHz, 1.5 µm resolution SD-OCT forBiomedical optics express · 2018Article
- Article
- Normative Values of Peripapillary Retinal Nerve Fiber Layer Thickness in a Middle Eastern Population.Journal of ophthalmology · 2018Article
- Deformation velocity imaging using optical coherence tomography and its applications to the cornea.Biomedical optics express · 2017Article
- Sub-micrometer axial resolution OCT forBiomedical optics express · 2017Article
- Ultrahigh-resolution OCT imaging of the human cornea.Biomedical optics express · 2017Article
- Optical Assessment of Soft Contact Lens Edge-Thickness.Optometry and vision science : official publication of the American Academy of Optometry · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Gabor-domain optical coherence microscopy (GD-OCM) was applied ex vivo in the investigation of corneal cells and their surrounding microstructures with particular attention to the corneal endothelium. Experiments using fresh pig eyeballs, excised human corneal buttons from patients with Fuchs' endothelial dystrophy (FED), and healthy donor corneas were conducted. Results show in a large field of view (1 mm×1 mm) high definition images of the different cell types and their surrounding microstructures through the full corneal thickness at both the central and peripheral locations of porcine corneas. Particularly, an image of the endothelial cells lining the bottom of the cornea is highlighted. As compared to healthy human corneas, the corneas of individuals with FED show characteristic microstructural alterations of the Descemet's membrane and increased size and number of keratocytes. The GD-OCM-based imaging system developed may constitute a novel tool for corneal imaging and disease diagnosis. Also, importantly, it may provide insights into the mechanism of corneal physiology and pathology, particularly in diseases of the corneal endothelium.
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