ArticleEnvironmental health perspectives2015
Insights into PBDE Uptake, Body Burden, and Elimination Gained from Australian Age-Concentration Trends Observed Shortly after Peak Exposure.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promoting SIRT1/SIRT3/FOXO3a-Dependent Mitochondrial Quality Control.Antioxidants (Basel, Switzerland) · 2026Article
- Correlates of plasma concentrations of brominated flame retardants in a cohort of U.S. Black women residing in the Detroit, Michigan metropolitan area.The Science of the total environment · 2020Article
- Temporal trends and developmental patterns of plasma polybrominated diphenyl ether concentrations over a 15-year period between 1998 and 2013.Journal of exposure science & environmental epidemiology · 2019Article
- Temporal trends in serum polybrominated diphenyl ether concentrations in the Australian population, 2002-2013.Environment international · 2018Article
- Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs): A six-year temporal trend in Northern California pregnant women.Chemosphere · 2018Article
- Recommendations for Evaluating Temporal Trends of Persistent Organic Pollutants in Breast Milk.Environmental health perspectives · 2016Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPopulation pharmacokinetic models combined with multiple sets of age-concentration biomonitoring data facilitate back-calculation of chemical uptake rates from biomonitoring data.
objectivesWe back-calculated uptake rates of PBDEs for the Australian population from multiple biomonitoring surveys (top-down) and compared them with uptake rates calculated from dietary intake estimates of PBDEs and PBDE concentrations in dust (bottom-up).
methodsUsing three sets of PBDE elimination half-lives, we applied a population pharmacokinetic model to the PBDE biomonitoring data measured between 2002-2003 and 2010-2011 to derive the top-down uptake rates of four key PBDE congeners and six age groups. For the bottom-up approach, we used PBDE concentrations measured around 2005.
resultsTop-down uptake rates of Σ4BDE (the sum of BDEs 47, 99, 100, and 153) varied from 7.9 to 19 ng/kg/day for toddlers and from 1.2 to 3.0 ng/kg/day for adults; in most cases, they were--for all age groups--higher than the bottom-up uptake rates. The discrepancy was largest for toddlers with factors up to 7-15 depending on the congener. Despite different elimination half-lives of the four congeners, the age-concentration trends showed no increase in concentration with age and were similar for all congeners.
conclusionsIn the bottom-up approach, PBDE uptake is underestimated; currently known pathways are not sufficient to explain measured PBDE concentrations, especially in young children. Although PBDE exposure of toddlers has declined in the past years, pre- and postnatal exposure to PBDEs has remained almost constant because the mothers' PBDE body burden has not yet decreased substantially.
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