ArticleJournal of psychiatry & neuroscience : JPN2015
Grey matter, an endophenotype for schizophrenia? A voxel-based morphometry study in siblings of patients with schizophrenia.
Article in Journal of psychiatry & neuroscience : JPN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain structural correlates of familial risk for mental illness: a meta-analysis of voxel-based morphometry studies in relatives of patients with psychotic or mood disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Pooled it
- Investigating The Brain Regions Related to Early Onset Psychosis: A Voxel-Based Morphometry Study Considering The Effect of Hereditary Burden and Environmental Risk Factors.Noro psikiyatri arsivi · 2025Article
- Gray Matter Volume Changes in Patients With Acute Eye Pain: A Voxel-Based Morphometry Study.Translational vision science & technology · 2019Article
- Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia.Frontiers in neuroscience · 2018Article
- Voxel-based gray and white matter morphometry correlates of hallucinations in schizophrenia: The superior temporal gyrus does not stand alone.NeuroImage. Clinical · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
backgroundGrey matter, both volume and concentration, has been proposed as an endophenotype for schizophrenia given a number of reports of grey matter abnormalities in relatives of patients with schizophrenia. However, previous studies on grey matter abnormalities in relatives have produced inconsistent results. The aim of the present study was to examine grey matter differences between controls and siblings of patients with schizophrenia and to examine whether the age, genetic loading or subclinical psychotic symptoms of selected individuals could explain the previously reported inconsistencies.
methodsWe compared the grey matter volume and grey matter concentration of healthy siblings of patients with schizophrenia and healthy controls matched for age, sex and education using voxel-based morphometry (VBM). Furthermore, we selected subsamples based on age (< 30 yr), genetic loading and subclinical psychotic symptoms to examine whether this would lead to different results.
resultsWe included 89 siblings and 69 controls in our study. The results showed that siblings and controls did not differ significantly on grey matter volume or concentration. Furthermore, specifically selecting participants based on age, genetic loading or subclinical psychotic symptoms did not alter these findings. LIMITATIONS: The main limitation was that subdividing the sample resulted in smaller samples for the subanalyses. Furthermore, we used MRI data from 2 different scanner sites.
conclusionThese results indicate that grey matter measured through VBM might not be a suitable endophenotype for schizophrenia.
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