ArticlePloS one2015
Gender-based differences on the association between salt-sensitive genes and obesity in Korean children aged between 8 and 9 years.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Elevation of Fasting Ghrelin in Healthy Human Subjects Consuming a High-Salt Diet: A Novel Mechanism of Obesity?Nutrients · 2016Trial
- Daily Sodium Intake Based on Random Urinary Excretion in Children Aged 6-24 Months and Associated Risk Factors.Pediatric gastroenterology, hepatology & nutrition · 2026Article
- The association between the GNB3 rs5443 C/C genotype and obesity phenotypes in Taiwanese individuals.BioMedicine · 2026Article
- G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Dopamine Receptor DThe Yale journal of biology and medicine · 2023Review
- Inverse Salt Sensitivity of Blood Pressure Is Associated with an Increased Renin-Angiotensin System Activity.Biomedicines · 2022Article
- Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.Pharmacology & therapeutics · 2022Review
- Inverse Salt Sensitivity of Blood Pressure: Mechanisms and Potential Relevance for Prevention of Cardiovascular Disease.Current hypertension reports · 2022Review
- Article
- RMR-RelatedJournal of personalized medicine · 2021Article
- The Hypertension Related Gene G-Protein Coupled Receptor Kinase 4 Contributes to Breast Cancer Proliferation.Breast cancer : basic and clinical research · 2021Article
- Female Sex, a Major Risk Factor for Salt-Sensitive Hypertension.Current hypertension reports · 2020Review
- Research trends in obesity & obesogenic environments in Korea.Nutrition research and practice · 2019Review
- Factors Associated with High Sodium Intake Assessed from 24-hour Urinary Excretion and the Potential Effect of Energy Intake.Journal of nutrition and metabolism · 2019Article
- Genetic variants of SLC12A3 modulate serum lipid profiles in a group of Mongolian pedigree population.Lipids in health and disease · 2018Article
- The impacts of the interaction of genetic variation, CYP11β2 and NEDD4L, with sodium intake on pediatric obesity with gender difference: a 3-year panel study.International journal of obesity (2005) · 2017Article
- Association between GNB3 c.825C > T polymorphism and the risk of overweight and obesity: A meta-analysis.Meta gene · 2016Article
- Gastrorenal Axis.Hypertension (Dallas, Tex. : 1979) · 2016Review
- The Role of Aldosterone in Obesity-Related Hypertension.American journal of hypertension · 2016Review
- Genomics and pharmacogenomics of salt-sensitive hypertension Minireview.Current hypertension reviews · 2015Article
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6 authors.
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Abstract
backgroundHigh sodium intake is associated with the development of chronic diseases such as obesity. Although its role in obesity remains controversial, there may be a correlation between salt sensitivity and the early onset of chronic diseases in obese children.
methodsIn all, 2,163 Korean children (1,106 boys and 1,057 girls) aged 8-9 years were recruited from seven elementary schools in Seoul. To evaluate whether obesity risk was modulated by the salt sensitivity, 11 SNPs related to salt sensitive genes (SSG) became the target of sodium intakes in obese children.
resultsBP, HOMA-IR, LDLc, TG, and the girls' sodium intake significantly increased, but HDLc significantly decreased with increase in BMI. Regardless of sex, the obesity risk was 5.27-fold (CI; 1.320-27.560) higher in the Q2 to Q5 of sodium intake adjusted by energy (4044.9-5058.9 mg/day) than in the lowest Q1 level (2287.6 mg/day) in obese children. BP was sensitively dependent on insulin resistance and lipid accumulation in all subjects; however, sodium intake may be an independent risk factor of obesity without increasing BP in girls. GRK4 A486V mutant homozygote was highly distributed in the obese group, but other SNPs had no impact. The obesity risk increased 7.06, 16.8, and 46.09-fold more in boys with GRK4 A486V, ACE, and SLC12A3 mutants as sodium intake increased. Among girls, the obesity risk increased in GRK4 A486V heterozygote and CYP11β-2 mutant homozygote although sodium intake was relatively lower, implying that ACE, SLC12A, CYP11β-2, and GRK4 A486V polymorphisms showed gender-based differences with regard to interaction between sodium intake and obesity.
conclusionA high sodium intake markedly increased the obesity risk in variants of GRK4 A486V regardless of sex. The obesity risk increased with GRK4 A486V, ACE, and SLC12A3 variants in boys, whereas it increased with GRK4 A486V and CYP11B2 variants in girls as sodium intake increased. Obese children with the specific gene variants are recommended to reduce their sodium intake.
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