ArticlePloS one2015
Significant reduction of antibiotic consumption and patients' costs after an action plan in China, 2010-2014.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antibiotic stewardship interventions in hospitals in low-and middle-income countries: a systematic review.Bulletin of the World Health Organization · 2018Pooled it
- Antibiotic Consumption Patterns in Three Romanian Hospitals: A Five-Year Retrospective Study.Antibiotics (Basel, Switzerland) · 2026Article
- Global trends in inappropriate use of antibiotics, 2000-2021: scoping review and prevalence estimates.BMJ public health · 2025Article
- Article
- Use of antibiotics and other treatments in Chinese adults with acute cough: An online survey.Integrative medicine research · 2023Article
- Long-term trend of antibiotic use at public health care institutions in northwest China, 2012-20 -- a case study of Gansu Province.BMC public health · 2023Article
- Overuse of medications in low- and middle-income countries: a scoping review.Bulletin of the World Health Organization · 2023Article
- Genomic Epidemiology of Carbapenemase-producing Klebsiella pneumoniae in China.Genomics, proteomics & bioinformatics · 2022Article
- Effectiveness of Educational Interventions for Health Workers on Antibiotic Prescribing in Outpatient Settings in China: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2022Review
- Interventions to optimize the use of antibiotics in China: A scoping review of evidence from humans, animals, and the environment from a One Health perspective.One health (Amsterdam, Netherlands) · 2022Article
- Developing a theory-based behavior change intervention to improve the prescription of surgical prophylaxis.International journal of clinical pharmacy · 2022Article
- Strategies to Improve Antimicrobial Utilization with a Special Focus on Developing Countries.Life (Basel, Switzerland) · 2021Review
- Current Practices in Missing Data Handling for Interrupted Time Series Studies Performed on Individual-Level Data: A Scoping Review in Health Research.Clinical epidemiology · 2021Article
- Trends and Patterns of Antibiotics Use in China's Urban Tertiary Hospitals, 2016-19.Frontiers in pharmacology · 2021Article
- Analysis of Antibiotic Consumption by AWaRe Classification in Shandong Province, China, 2012-2019: A Panel Data Analysis.Frontiers in pharmacology · 2021Article
- Key Issues Surrounding Appropriate Antibiotic Use for Prevention of Surgical Site Infections in Low- and Middle-Income Countries: A Narrative Review and the Implications.International journal of general medicine · 2021Review
- Characteristics of prescriptions and costs for acute upper respiratory tract infections in Chinese outpatient pediatric patients: a nationwide cross-sectional study.BMC complementary medicine and therapies · 2020Article
- Effects of restrictive-prescribing stewardship on antibiotic consumption in primary care in China: an interrupted time series analysis, 2012-2017.Antimicrobial resistance and infection control · 2020Article
- Patients without records and records without patients: review of patient records in primary care and implications for surveillance of antibiotic prescribing in rural China.BMC health services research · 2020Article
- The impact of physicians' knowledge on outpatient antibiotic use: Evidence from China's county hospitals.Medicine · 2020Article
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Authors and funding
34 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOn July 1, 2011, the Chinese government launched a national Action Plan for antibiotic stewardship targeting antibiotic misuse in public hospitals. The aim of this study was to evaluate the impacts of the Action Plan in terms of frequency and intensity of antibiotic utilization and patients costs in public general hospitals.
methodsAdministrative pharmacy data from July 2010 to June 2014 were sampled from 65 public general hospitals and divided into three segments: (1) July 2010 to June 2011 as the preparation period; (2) July 2011 to June 2012 as the intervention period; and (3) July 2012 to June 2014 as the assessment period. The outcome measures included (1) antibiotic prescribing rates; (2) intensity of antibiotic consumption; (3) patients costs; and (4) duration of peri-operative antibiotic treatment in clean surgeries of thyroidectomy, breast, hernia, and orthopedic procedures. Longitudinal and cross-sectional analyses were conducted.
resultsLongitudinal analyses showed significant trend changes in the frequency and intensity of antibiotic consumption, the patients' costs on antibiotics, and the duration of antibiotic treatment received by surgical patients undergoing the 4 clean procedures during the intervention period. Cross-sectional analyses showed that the antibiotic prescribing rates were reduced to 35.3% and 12.9% in inpatient and outpatient settings, that the intensity of antibiotic consumption was reduced to 35.9 DDD/100 bed-days, that patients' costs on antibiotics were reduced significantly, and that the duration of peri-operative antibiotic treatment received by surgical patients undergoing the 4 types of clean procedures decreased to less than 24 hour during the assessment period.
conclusionThe Action Plan, as a combination of managerial and professional strategies, was effective in reducing the frequency and intensity of antibiotic consumption, patients' costs on antibiotics, and the duration of peri-operative antibiotic treatment in the 4 clean surgeries.
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