ArticlePloS one2015
Tracking the fate of stem cell implants with fluorine-19 MRI.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Systems Engineering Approach Towards Sensitive Cellular Fluorine-19 MRI.NMR in biomedicine · 2025Review
- Pivotal role of the protein corona in the cell uptake of fluorinated nanoparticles with increased sensitivity forNanoscale advances · 2023Article
- Method for estimation of apoptotic cell fraction of cytotherapy using in vivo fluorine-19 magnetic resonance: pilot study in a patient with head and neck carcinoma receiving tumor-infiltrating lymphocytes labeled with perfluorocarbon nanoemulsion.Journal for immunotherapy of cancer · 2023Article
- Reporter Genes for Brain Imaging Using MRI, SPECT and PET.International journal of molecular sciences · 2022Review
- In vivo tracking of unlabelled mesenchymal stromal cells by mannose-weighted chemical exchange saturation transfer MRI.Nature biomedical engineering · 2022Article
- Click-Ready Perfluorocarbon Nanoemulsion forACS nanoscience Au · 2022Article
- Article
- Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective.Cytotherapy · 2021Review
- Emergent Fluorous Molecules and Their Uses in Molecular Imaging.Accounts of chemical research · 2021Article
- A Perspective on Cell Tracking with Magnetic Particle Imaging.Tomography (Ann Arbor, Mich.) · 2020Article
- 7-T MRI tracking of mesenchymal stromal cells after lung injection in a rat model.European radiology experimental · 2020Article
- In vivo stem cell tracking using scintigraphy in a canine model of DMD.Scientific reports · 2020Article
- Fluorine-19 Cellular MRI Detection of In Vivo Dendritic Cell Migration and Subsequent Induction of Tumor Antigen-Specific Immunotherapeutic Response.Molecular imaging and biology · 2020Article
- Comparative strategies for stem cell biodistribution in a preclinical study.Acta pharmacologica Sinica · 2020Article
- Perfluorocarbons-BasedInternational journal of nanomedicine · 2020Review
- Trimodal Cell Tracking In Vivo: Combining Iron- and Fluorine-Based Magnetic Resonance Imaging with Magnetic Particle Imaging to Monitor the Delivery of Mesenchymal Stem Cells and the Ensuing Inflammation.Tomography (Ann Arbor, Mich.) · 2019Article
- A Trimodal Imaging Platform for Tracking Viable Transplanted Pancreatic Islets In Vivo: F-19 MR, Fluorescence, and Bioluminescence Imaging.Molecular imaging and biology · 2019Article
- Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI.Journal of neuro-oncology · 2019Article
- Improvement ofMagma (New York, N.Y.) · 2019Article
- PreclinicalMagma (New York, N.Y.) · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this study we used cellular magnetic resonance imaging (MRI) to detect mesenchymal stem cells (MSC) labeled with a Fluorine-19 (19F) agent. 19F-MRI offers unambiguous detection and in vivo quantification of labeled cells.
methodsWe investigated two common stem cell transplant mouse models: an immune competent, syngeneic transplant model and an immune compromised, xenograft transplant model. 19F labelled stem cells were implanted intramuscularly into the hindlimb of healthy mice. The transplant was then monitored for up to 17 days using 19F-MRI, after which the tissue was excised for fluorescence microscopy and immunohistochemisty.
resultsImmediately following transplantation, 19F-MRI quantification correlated very well with the expected cell number in both models. The 19F signal decreased over time in both models, with a more rapid decrease in the syngeneic model. By endpoint, only 2/7 syngeneic mice had any detectable 19F signal. In the xenograft model, all mice had detectable signal at endpoint. Fluorescence microscopy and immunohistochemistry were used to show that the 19F signal was related to the presence of bystander labeled macrophages, and not original MSC.
conclusionsOur results show that 19F-MRI is an excellent tool for verifying the delivery of therapeutic cells early after transplantation. However, in certain circumstances the transfer of cellular label to other bystander cells may confuse interpretation of the long-term fate of the transplanted cells.
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