Diverse muscle architecture adaptations in a rabbit tibial lengthening model.

Mitsuhiko Takahashi, Natsuo Yasui, Tetsuya Enishi, Nori Sato, Takatoshi Mizobuchi, Yukako Homma, Koichi Sairyo

Abstract read

In one paragraph

Article in Muscles, ligaments and tendons journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mitsuhiko TakahashiThe Institute of Health BioSciences, the University of Tokushima, Japan.

Natsuo YasuiThe Institute of Health BioSciences, the University of Tokushima, Japan.

Tetsuya EnishiThe Institute of Health BioSciences, the University of Tokushima, Japan.

Nori SatoThe Institute of Health BioSciences, the University of Tokushima, Japan.

Takatoshi MizobuchiThe Institute of Health BioSciences, the University of Tokushima, Japan.

Yukako HommaThe Institute of Health BioSciences, the University of Tokushima, Japan.

Koichi SairyoThe Institute of Health BioSciences, the University of Tokushima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundduring limb lengthening, muscles are thought to increase the number of sarcomeres. However, this adaptation may differ among muscles with diverse architecture. PURPOSE: this study wish to clarify the differences in muscle adaptation in a rabbit model of tibial lengthening.

methodstwelve rabbits underwent tibial lengthening (0.7 mm/day for 4 weeks), with the contralateral limb serving as a control, and were euthanized after either the lengthening or the consolidation period. Six muscles around the tibia were investigated in terms of muscle belly length, muscle weight, sarcomere length and serial sarcomere number.

resultsmuscle belly length increased in all the lengthened muscles. No increases in muscle mass were noted. Sarcomere length increased in the ankle plantar-flexors and was kept longer than the optimal sarcomere length after the consolidation period. Nevertheless, significant increases in sarcomere number were observed in two ankle plantar-flexors.

conclusionthis study demonstrated that muscle belly length largely adapted to the lengthening. The increase in sarcomere number did not match the increase in muscle belly length. We estimated that elongation of the intramuscular aponeuroses is another mechanism of the adaptation in addition to the increase in sarcomere number.

Indexed as

aponeurosislimb lengtheningmuscle adaptationmuscle architecturesarcomere number

Identifiers

PMID25767780

PMCPMC4327352

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.