ArticleJournal of ophthalmology2015
The impact of migraine on posterior ocular structures.
Article in Journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Retinal nerve fiber layer changes in migraine: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Retinal optical coherence tomography angiography findings in the new- onset migraine patients: a prospective case-control study.BMC ophthalmology · 2026Article
- Vascular Changes in the Macula and Peripapillary Regions Using Optical Coherence Tomography Angiography in Migraine with Aura and Migraine Without Aura.Journal of clinical medicine · 2026Article
- Optical coherence tomography is a useful tool for monitoring treatment response in migraine: a prospective longitudinal study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Evaluation of macular and peripapillary structure and microvasculature with optical coherence tomography angiography in migraine in the Indian population.World journal of methodology · 2025Article
- Evaluation of nerve fiber layer and ganglion cell complex changes in patients with migraine using optical coherence tomography.eNeurologicalSci · 2024Article
- Clinical Characteristics of Migraine and Their Association With the Retinal Nerve Fiber Layer Thickness.Cureus · 2024Article
- Frequency of migraine and its associated triggers and relievers among medical students of Lahore: a cross-sectional study.Annals of medicine and surgery (2012) · 2024Article
- Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review.Frontiers in neuroscience · 2024Review
- Article
- L-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-II trial (LARGE trial).BMC neurology · 2023Article
- Decrease Retinal Thickness in Patients with Chronic Migraine Evaluated by Optical Coherence Tomography.Diagnostics (Basel, Switzerland) · 2022Article
- Glaucoma and optical coherence tomography changes in migraine: A comparative cross-sectional study.Indian journal of ophthalmology · 2021Article
- Evaluation of migraine patients with optical coherence tomography angiography.International ophthalmology · 2021Article
- Evaluation of retinal vessel density and choriocapillaris flow in migraine patients with and without aura.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study.Antioxidants (Basel, Switzerland) · 2020Article
- EDI-OCT choroidal thickness in Posner-Schlossman syndrome.International ophthalmology · 2020Observational
- Altered Macular Vasculature in Migraine Patients without Aura: Is It Associated with Ocular Vasculature and White Matter Hyperintensities?Journal of ophthalmology · 2020Article
- Evaluation of white matter hyperintensities and retinal fiber layer, ganglion cell layer, inner-plexiform layer, and choroidal layer in migraine patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Foveal and Peripapillary Vascular Decrement in Migraine With Aura Demonstrated by Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose. To investigate the thickness of the retinal nerve fiber layer (RNFL) and choroid in patients who have migraines in comparison to healthy controls. Methods. This study included 76 eyes and patients in the migraine group, 36 with aura (MWA group) and 40 without (MWoA group), and 38 eyes as control subjects. The RNFL and macular thicknesses were analysed with standard OCT protocol while choroidal thickness was analysed with EDI protocol in all subjects. Choroidal thickness was measured at the fovea, 1500 µm nasal and 1500 µm temporal to the fovea in a horizontal section. Results. The mean RNFL thickness for nasal and nasal inferior sectors was significantly thinner (P ≤ 0.018) in the migraineurs' eyes than in those of the controls, as was the mean choroid thickness at the fovea and measured points (P < 0.0001). However, the mean macular thickness was not significantly different between the groups. Conclusions. This study suggests that migraine leads to a reduction in the peripapillary RNFL thickness and to thinning in choroidal structures. These findings can be explained by a chronic ischemic insult related to migraine pathogenic mechanisms and these findings are considered supportive of the relationship between glaucoma and migraine.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.