ArticleTherapeutics and clinical risk management2015
Therapeutic effect of hybrid training of voluntary and electrical muscle contractions in middle-aged obese women with nonalcoholic fatty liver disease: a pilot trial.
Article in Therapeutics and clinical risk management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- In middle-aged and old obese patients, training intervention reduces leptin level: A meta-analysis.PloS one · 2017Pooled it
- "Hybrid exercise training improves liver steatosis and inflammation in a randomized trial of sedentary, obese women with non-alcoholic fatty liver disease".BMC sports science, medicine & rehabilitation · 2025Article
- Skeletal muscle and MASLD: Mechanistic and clinical insights.Hepatology communications · 2025Review
- Blood, sweat, tears and fibrosis: when overtraining injures the liver.Extracellular vesicles and circulating nucleic acids · 2025Article
- Exercise-Induced Increase in Serum Irisin Levels is Associated with Antioxidant Effects of Silymarin in Dexamethasone- Induced NAFLD.International journal of preventive medicine · 2025Article
- Myosteatosis: Diagnosis, pathophysiology and consequences in metabolic dysfunction-associated steatotic liver disease.JHEP reports : innovation in hepatology · 2024Review
- Exercise in the Management of Metabolic-Associated Fatty Liver Disease (MAFLD) in Adults: A Position Statement from Exercise and Sport Science Australia.Sports medicine (Auckland, N.Z.) · 2023Review
- Clinical practice advice on lifestyle modification in the management of nonalcoholic fatty liver disease in Japan: an expert review.Journal of gastroenterology · 2021Review
- Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women.Medicina (Kaunas, Lithuania) · 2019Article
- Whole-body vibration for patients with nonalcoholic fatty liver disease: a 6-month prospective study.Physiological reports · 2019Article
- Physical Fitness and Its Relationship to Plasma Leptin, Leptin Soluble Receptor, and Free Leptin Index in a Saudi Population: A Comparison Between Diabetic and Non-Diabetic Individuals.Medical science monitor basic research · 2018Article
- The Effects of Physical Exercise on Fatty Liver Disease.Gene expression · 2018Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExercise training is an effective therapy for nonalcoholic fatty liver disease (NAFLD). Hybrid training (HYB) of voluntary and electrical muscle contractions was developed to prevent disuse atrophy during space flight. HYB can be applied to obtain a strength training effect accompanying articular movement. In this pilot study, we aimed to investigate the therapeutic efficacy of HYB in NAFLD.
methodsA total of 15 middle-aged obese women with NAFLD who had no improvement in serum alanine aminotransferase levels and/or liver fat deposition after 12 weeks of lifestyle counseling participated in an HYB program. HYB of the quadriceps and hamstrings was conducted for 20 minutes twice a week for 24 weeks.
resultsNAFLD patients showed attenuated intramyocellular lipid levels in the quadriceps after the HYB intervention (-15.5%). Levels of leptin (-17.4%), tumor necrosis factor-α (-23.2%), and interleukin-6 (-30.5%) were also decreased after the intervention. HYB led to a significant body weight reduction (-4.7%), which in turn was associated with a significant decrease in serum alanine aminotransferase (-35.8%), gamma-glutamyl transpeptidase (-21.6%), ferritin (-16.0%), oxidative stress (-17.8%) levels, and insulin resistance values (-2.7%).
conclusionIn NAFLD, HYB exerts an antiobesity effect and attenuates liver dysfunction and insulin resistance in association with an increase in muscle strength and a decrease in ectopic muscle fat. Therefore, HYB has great potential as a new type of exercise therapy for liver disease in patients with NAFLD.
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