ArticleJournal of basic and clinical pharmacy2015
Antiedematogenic and antioxidant properties of high molecular weight protein sub-fraction of Calotropis procera latex in rat.
Article in Journal of basic and clinical pharmacy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Green synthesis of zinc oxide (ZnO) nanoparticles using aqueous leaves extracts ofHelminthologia · 2025Article
- Anti-inflammatory latex proteins of the medicinal plant Calotropis procera: a promising alternative for oral mucositis treatment.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Latex proteins downregulate inflammation and restores blood-coagulation homeostasis in acute Salmonella infection.Memorias do Instituto Oswaldo Cruz · 2020Article
- Cytotoxicity against tumor cell lines and anti-inflammatory properties of chitinases from Calotropis procera latex.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Wound healing modulation by a latex protein-containing polyvinyl alcohol biomembrane.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Protective Effect of High Molecular Weight Protein Sub-fraction of Calotropis procera Latex in Monoarthritic Rats.Pharmacognosy magazine · 2016Article
- Impact of phenolic composition on hepatoprotective and antioxidant effects of four desert medicinal plants.BMC complementary and alternative medicine · 2015Article
- The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K ATP Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim was to evaluate the effect of high molecular weight protein fraction of Calotropis procera latex on edema formation and oxidative stress in carrageenan-induced paw inflammation.
methodsA sub-plantar injection of carrageenan was given to induce edema in the hind paw of the rat. The inhibitory effect of high molecular weight protein fraction of C. procera latex was evaluated following intravenous administration (5 and 25 mg/kg body weight) and was compared with that of diclofenac given orally (5 mg/kg). The levels of reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and myeloperoxidase (MPO) were measured in the inflamed paw tissue at the end of the study.
resultsThe high molecular weight protein fraction obtained from the latex of C. procera produced a dose-dependent inhibition of edema formation that was accompanied by normalization of levels of oxidative stress markers (GSH and TBARS) and MPO, a marker for neutrophils in the paw tissue.
conclusionsThe high molecular weight protein fraction of C. procera latex ameliorates acute inflammation in the paw through its antioxidant effect.
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