Evidence map›Paper›PMID 25767138›Full record

SynthesisChronic respiratory disease2015

A combination of resistance and endurance training increases leg muscle strength in COPD: An evidence-based recommendation based on systematic review with meta-analyses.

Ulrik Winning Iepsen, Karsten Juhl Jørgensen, Thomas Ringbæk, Henrik Hansen, Conni Skrubbeltrang, Peter Lange

Open access · hybridAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Chronic respiratory disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. German recommendations for physical activity and physical activity promotion in adults with noncommunicable diseases.The international journal of behavioral nutrition and physical activity · 2020
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study.International journal of chronic obstructive pulmonary disease · 2016
    Trial
  8. Trial
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Exercise and Chronic Obstructive Pulmonary Disease (COPD).Advances in experimental medicine and biology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Ulrik Winning IepsenCentre of Inflammation and Metabolism/Centre for Physical Activity Research, Department of Infectious Diseases, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark ulrik_winning@hotmail.com.
Karsten Juhl JørgensenThe Nordic Cochrane Centre, Rigshospitalet, Copenhagen, Denmark.
Thomas RingbækDepartment of Respiratory Medicine, University Hospital Hvidovre, Hvidovre, Denmark.
Henrik HansenMunicipality of Copenhagen, Vordingborggade, Copenhagen, Denmark.
Conni SkrubbeltrangMedical Library, Aalborg University Hospital, Hobrovej, Aalborg, Denmark.
Peter LangeCentre of Inflammation and Metabolism/Centre for Physical Activity Research, Department of Infectious Diseases, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark Department of Respiratory Medicine, University Hospital Hvidovre, Hvidovre, Denmark Department of Public Health, Section of Social Medicine, University of Copenhagen, Copenhagen, Denmark.
Aalborg University Hospital · DKCochrane · DKCopenhagen Municipal Hospital · DKHvidovre Hospital · DKRigshospitalet · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance training (RT) is thought to be effective in preventing muscle depletion, whereas endurance training (ET) is known to improve exercise capacity and health-related quality of life (HRQoL) in chronic obstructive pulmonary disease (COPD). Our objectives were to assess the efficiency of combining RT with ET compared with ET alone. We identified eligible studies through a systematic multi-database search. One author checked titles and abstracts for relevance using broad inclusion criteria, whilst two independent authors checked the full-text copies for eligibility. Two authors independently extracted data, and we assessed the risk of bias and quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation guidelines. We included 11 randomized controlled trials (331 participants) and 2 previous systematic reviews. The meta-analyses showed equal improvements in HRQoL, walking distance and exercise capacity. However, we found moderate quality evidence of a significant increase in leg muscle strength favouring a combination of RT and ET (standardized mean difference of 0.69 (95% confidence interval: 0.39-0.98). In conclusion, we found significantly increased leg muscle strength favouring a combination of RT with ET compared with ET alone. Therefore, we recommend that RT should be incorporated in rehabilitation of COPD together with ET.

Indexed as

Muscle StrengthEvidence-Based MedicineExercise TherapyExercise ToleranceHumansLegPulmonary Disease, Chronic ObstructiveResistance TrainingTreatment Outcomechronic obstructiveexercise therapymuscle depletionphysical therapy modalitiespractice guidelinePulmonary diseasereviewsystematic

Identifiers

PMID25767138
PMCPMC4412880
OpenAlexW2065783382

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.