Observational studyEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2016
Pulmonary embolism in patients with transvenous cardiac implantable electronic device leads.
Observational study in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Pacemaker therapy through a sex-specific lens: a narrative review of clinical and procedural disparities.Frontiers in cardiovascular medicine · 2026Review
- Infectious mass debulking in lead-associated endocarditis with a percutaneous aspiration system.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Observational
- A Rare Cause of Pulmonary Embolism: Lead Fracture in an Unexpected Area.Journal of clinical practice and research · 2024Article
- Brazilian Guidelines for Cardiac Implantable Electronic Devices - 2023.Arquivos brasileiros de cardiologia · 2023Article
- Case report: Unusual cause of refractory hypoxemia after pacemaker lead extraction.Frontiers in cardiovascular medicine · 2023Article
- Lead-related infective endocarditis with vegetations: Prevalence and impact of pulmonary embolism in patients undergoing transvenous lead extraction.Journal of cardiovascular electrophysiology · 2022Article
- Idiopathic late coronary sinus lead dislodgement presenting with pulmonary embolism.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- Chronic thromboembolic pulmonary hypertension secondary to implantable cardioverter defibrillator lead thrombus in a patient with Brugada syndrome: a rare complication requiring a multidisciplinary approach.BMJ case reports · 2020Article
- Usefulness of preoperative venography in patients with cardiac implantable electronic devices submitted to lead replacement or device upgrade procedures.Arquivos brasileiros de cardiologia · 2018Article
- Real-Time Embolization of a Massive Lead-Associated Thrombus Visualized by Transesophageal Echocardiography.CASE (Philadelphia, Pa.) · 2018Article
- Case report: recurrent thrombosis of an old lead of a DDDR pacemaker mimicking lead infection.European heart journal. Case reports · 2018Article
- Endocardial Device Leads in Patients with Patent Foramen Ovale: Echocardiographic Correlates of Stroke/TIA and Mortality.Pacing and clinical electrophysiology : PACE · 2017Article
- Cardiac implantable electronic device lead-based masses and atrial fibrillation ablation: a case-based illustration of periprocedural anticoagulation management strategies.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2016Article
- Mobile thrombus on cardiac implantable electronic device leads of patients undergoing cardiac ablation: incidence, management, and outcomes.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2016Article
- Considerations for cardiac device lead extraction.Nature reviews. Cardiology · 2016Review
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundCardiac implantable electronic devices (CIEDs) are commonly associated with transvenous lead-related thrombi that can cause pulmonary embolism (PE). METHODS AND
resultsWe retrospectively evaluated all patients with transvenous CIED leads implanted at Mayo Clinic Rochester between 1 January 2000, and 25 October 2010. Pulmonary embolism outcomes during follow-up were screened using diagnosis codes and confirmed with imaging study reports. Of 5646 CIED patients (age 67.3 ± 16.3 years, 64% men, mean follow-up 4.69 years) 88 developed PE (1.6%), incidence 3.32 [95% confidence interval (CI) 2.68-4.07] per 1000 person-years [men: 3.04 (95% CI 2.29-3.96) per 1000 person-years; women: 3.81 (95% CI 2.72-5.20) per 1000 person-years]. Other than transvenous CIED lead(s), 84% had another established risk factor for PE such as deep vein thrombosis (28%), recent surgery (27%), malignancy (25%), or prior history of venous thromboembolism (15%). At the time of PE, 22% had been hospitalized for ≥ 48 h, and 59% had been hospitalized in the preceding 30 days. Pulmonary embolism occurred in 22% despite being on systemic anticoagulation therapy. Out of 88 patients with PE, 45 subsequently died, mortality rate 93 (95% CI 67-123) per 1000 person-years (hazard ratio 2.0, 95% CI 1.5-2.7, P < 0.0001).
conclusionsThough lead-related thrombus is commonly seen in patients with transvenous CIED leads, clinical PE occurs with a low incidence. It is possible that embolism of lead thrombus is uncommon or emboli are too small to cause consequential pulmonary infarction.
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