Observational studyJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2015
Improved Sleep Quality is Associated with Reductions in Depression and PTSD Arousal Symptoms and Increases in IGF-1 Concentrations.
Observational study in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Pooled it
- The Effects of Individual Psychotherapy in BDNF Levels of Patients With Mental Disorders: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- The effect of mindfulness meditation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.Annals of the New York Academy of Sciences · 2019Pooled it
- Cognitive behavioral therapy for insomnia treatment attrition in patients with weekly nightmares.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Trial
- Investigation of the effects of two exercise protocols on behavioral and biochemical changes in ovariectomized rats exposed to single prolonged stress.IBRO neuroscience reports · 2026Article
- Chronic military stress and glandular epithelial tumor biology: an integrative neuroendocrine-inflammatory framework with insights from microgravity gene discovery.Frontiers in oncology · 2026Article
- Horsepower: equine-assisted interventions are associated with reduced PTSD symptoms, improved sleep quality, and quality of life in military veterans with treatment-resistant PTSD.Frontiers in psychology · 2026Article
- Innovating through tradition: kava-Frontiers in psychology · 2025Review
- Prevalence of post-traumatic stress disorder in Peruvian military: a cross-sectional study.Frontiers in psychiatry · 2025Article
- Association between sarcopenia and sleep disorders: a cross-sectional population based study.Frontiers in nutrition · 2024Article
- The positive impact of smoking on poor sleep quality is moderated by IGF1 levels in cerebrospinal fluid: a case-control study among Chinese adults.Frontiers in psychiatry · 2024Article
- Interplay between stress, sleep, and BDNF in a high-risk sample of young adults.Scientific reports · 2023Article
- Article
- The Association between Sedentary Behavior, Physical Activity, and Physical Fitness with Body Mass Index and Sleep Time in Chilean Girls and Boys: A Cross-Sectional Study.Children (Basel, Switzerland) · 2023Article
- Acute sleep interventions as an avenue for treatment of trauma-associated disorders.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Factors associated with recovery from posttraumatic stress disorder in combat veterans: The role of deployment mild traumatic brain injury (mTBI).Rehabilitation psychology · 2022Article
- Sleep and PTSD in the Military Forces: A Reciprocal Relationship and a Psychiatric Approach.Brain sciences · 2021Review
- The Influence of Psychotherapy on Peripheral Brain-Derived Neurotrophic Factor Concentration Levels and Gene Methylation Status: A Systematic Review.Journal of clinical medicine · 2021Review
- Post traumatic stress symptom variation associated with sleep characteristics.BMC psychiatry · 2020Article
- Sleep, a Governor of Morbidity in PTSD: A Systematic Review of Biological Markers in PTSD-Related Sleep Disturbances.Nature and science of sleep · 2020Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
STUDY
objectivesOne-third of deployed military personnel will be diagnosed with insomnia, placing them at high risk for comorbid depression, posttraumatic stress disorder (PTSD), and medical conditions. The disruption of trophic factors has been implicated in these comorbid conditions, which can impede postdeployment recovery. This study determined if improved sleep quality is associated with (1) reductions in depression and posttraumatic symptoms, as well as enrichments in health-related quality of life (HRQOL), and (2) changes in plasma concentrations of brain derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1).
methodsForty-four military personnel diagnosed with insomnia underwent clinical evaluations and blood draws at pretreatment and at posttreatment following cognitive behavioral therapy for insomnia and automatic positive airway pressure treatment. Participants were classified as sleep improved (n = 28) or sleep declined (n = 16) based on their change in pretreatment to posttreatment Pittsburgh Sleep Quality Index (PSQI) score. Both groups were compared on outcomes of depression, PTSD, HRQOL, BDNF, and IGF-1.
resultsPaired t-tests of the sleep improved group revealed significant declines in depression (p = 0.005) and posttraumatic arousal (p = 0.006) symptoms, and a significant increase in concentrations of IGF-1 (p = 0.009). The sleep declined group had no relevant change in psychiatric symptoms or trophic factors, and had further declines on five of eight dimensions of HRQOL. Between-group change score differences were significant at p < 0.05.
conclusionsThese findings suggest that interventions, which successfully improve sleep quality, are an effective means to reduce the depression and posttraumatic arousal symptoms common to military personnel, as well as increase protective trophic factors implicated in these conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.