Observational studyJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2015
Noninvasive ventilation improves sleep in amyotrophic lateral sclerosis: a prospective polysomnographic study.
Observational study in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Prevalence of and associated factors for sleep disorders in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Impact of positive airway pressure for chronic hypercapnic respiratory failure on sleep quality: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Tolerability, Safety and Effectiveness of Sigh Introduction During Non-Invasive Mechanical Ventilation Cycles in Patients With Amyotrophic Lateral Sclerosis.European journal of neurology · 2026Trial
- Transcutaneous Carbon Dioxide Monitoring in Amyotrophic Lateral Sclerosis: A Scoping Review.European journal of neurology · 2026Article
- Factors associated with survival after early at-home NIV initiation in ALS patients.Journal of neurology · 2024Article
- Monitoring Systems in Home Ventilation.Journal of clinical medicine · 2023Review
- Article
- What is the right moment for noninvasive ventilation in amyotrophic lateral sclerosis?Archives of medical science : AMS · 2023Article
- Factors Associated with and Prognosis Impact of Perceived Sleep Quality and Estimated Quantity in Patients Receiving Non-Invasive Ventilation for Acute Respiratory Failure.Journal of clinical medicine · 2022Article
- Pathophysiology and Treatment of Non-motor Dysfunction in Amyotrophic Lateral Sclerosis.CNS drugs · 2021Review
- REINVENT: ERS International survey on REstrictive thoracic diseases IN long term home noninvasive VENTilation.ERJ open research · 2021Article
- Noninvasive Ventilation Use Is Associated with Better Survival in Amyotrophic Lateral Sclerosis.Annals of the American Thoracic Society · 2021Article
- Sleep and Sleep Disruption in Amyotrophic Lateral Sclerosis.Current neurology and neuroscience reports · 2020Review
- Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases.Acta neuropathologica communications · 2019Article
- Sleep in chronic respiratory disease: COPD and hypoventilation disorders.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Non-invasive ventilation in amyotrophic lateral sclerosis.Therapeutic advances in neurological disorders · 2019Review
- Respiratory Involvement in Patients with Neuromuscular Diseases: A Narrative Review.Pulmonary medicine · 2019Review
- Sleep disturbances in patients with amyotrophic lateral sclerosis: current perspectives.Nature and science of sleep · 2019Article
- Sleep disordered breathing in motor neurone disease.Journal of thoracic disease · 2018Review
- The predictive value of respiratory function tests for non-invasive ventilation in amyotrophic lateral sclerosis.Respiratory research · 2017Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveTo evaluate the effects of noninvasive ventilation (NIV) on sleep in patients with amyotrophic lateral sclerosis (ALS) after meticulous titration with polysomnography (PSG).
methodsIn this prospective observational study, 24 ALS patients were admitted to the sleep laboratory during 4 nights for in-hospital NIV titration with PSG and nocturnal capnography. Questionnaires were used to assess subjective sleep quality and quality of life (QoL). Patients were readmitted after one month.
resultsIn the total group, slow wave sleep and REM sleep increased and the arousal-awakening index improved. The group without bulbar involvement (non-bulbar) showed the same improvements, together with an increase in sleep efficiency. Nocturnal oxygen and carbon dioxide levels improved in the total and non-bulbar group. Except for oxygen saturation during REM sleep, no improvement in respiratory function or sleep structure was found in bulbar patients. However, these patients showed less room for improvement. Patient-reported outcomes showed improvement in sleep quality and QoL for the total and non-bulbar group, while bulbar patients only reported improvements in very few subscores.
conclusionsThis study shows an improvement of sleep architecture, carbon dioxide, and nocturnal oxygen saturation at the end of NIV titration and after one month of NIV in ALS patients. More studies are needed to identify the appropriate time to start NIV in bulbar patients. Our results suggest that accurate titration of NIV by PSG improves sleep quality. COMMENTARY: A commentary on this article appears in this issue on page 511.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.