ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2015
Continuous Positive Airway Pressure Treatment Increases Serum Vitamin D Levels in Male Patients with Obstructive Sleep Apnea.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers, 4 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Serum 25(OH)D levels and obstructive sleep apnea syndrome severity in patients without comorbidities: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Obstructive sleep apnea and vitamin D: an updated systematic review and meta-analysis.Hormones (Athens, Greece) · 2023Pooled it
- Relationship between obstructive sleep apnea-hypopnea syndrome and osteoporosis adults: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- The association between serum vitamin D and obstructive sleep apnea: an updated meta-analysis.Respiratory research · 2020Pooled it
- Expert consensus on osteoporosis risk management in patients with sleep disorders.Bone research · 2026Review
- Nephrolithiasis and obstructive sleep apnea: exploring shared pathways of inflammation, oxidative stress, and circadian disruption.World journal of urology · 2026Article
- Vitamin D Deficiency Is Associated with a Higher 5-Year Risk of Obstructive Sleep Apnea and CPAP Use in Older Adults: An Anchor-Based Network Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Article
- Vitamin D and Sleep Disorders.Advances in experimental medicine and biology · 2026Review
- A Prospective Observational Study Investigating the Relationship Between Vitamin D Deficiency and STOP-Bang Parameters in Elderly Populations.Nature and science of sleep · 2025Article
- Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea.Healthcare (Basel, Switzerland) · 2024Article
- Obstructive sleep apnea and vitamin D level: Has the dust settled?The clinical respiratory journal · 2024Review
- Continuous positive airway pressure treatment improves bone mineral density in men affected by severe obstructive sleep apnea syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Observational
- Effect of Continuous Positive Airway Pressure on Incident Frailty in Elderly Patients with Obstructive Sleep Apnea: A Study Based on Propensity Score Matching.Clinical interventions in aging · 2024Article
- Vitamin D Levels in Patients with Overlap Syndrome, Is It Associated with Disease Severity?Journal of personalized medicine · 2022Article
- Lumbar spine abnormalities in patients with obstructive sleep apnoea.Scientific reports · 2021Article
- Vitamin D deficiency in patients evaluated for obstructive sleep apnea: is it associated with disease severity?Sleep & breathing = Schlaf & Atmung · 2021Article
- Serum vitamin D levels in patients with obstructive sleep apnea syndrome and level changes after continuous positive airway pressure therapy.Sleep & breathing = Schlaf & Atmung · 2021Article
- Effect of regular resistance exercise, vitamin D, and calcium supplements on the bone mineral content and density in postmenopausal model of rats: An experimental study.International journal of reproductive biomedicine · 2021Article
- A meta-analysis: Does vitamin D play a promising role in sleep disorders?Food science & nutrition · 2020Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveRecent studies report a link between obstructive sleep apnea (OSA) syndrome, low vitamin D levels, and high parathyroid hormone (PTH) concentrations. The aim of the current study is to evaluate the effect of 7-night continuous positive airway pressure (CPAP) therapy on serum vitamin D, PTH, and calcium levels in patients with severe OSA syndrome.
methodsPatients with severe OSA were enrolled into the study and compared to control subjects. Patients with OSA underwent CPAP therapy for 7 nights and were consequently divided into responders (OSA-R, mean residual AHI < 5/h) and nonresponders (OSA-nR, mean residual AHI > 5/h). Serum vitamin D, PTH, and calcium levels were measured at baseline in patients with severe OSA (apnea-hypopnea index > 30/h) and control subjects. Patients with OSA underwent a final morning blood sample after 7-night CPAP therapy.
resultsWe enrolled 90 patients with OSA into the study (65 OSA-R and 25 OSA-nR) compared to 32 control subjects. At baseline, lower vitamin D and higher PTH levels were detected in the OSA group compared to controls. After 7-night CPAP therapy, male OSA-R patients showed a significant increase in vitamin D levels. Conversely, female OSA-R patients did not show the same increase in vitamin D levels. It was also observed that OSA-nR subjects did not show modifications of serum markers after nCPAP-therapy.
conclusionsThe study demonstrates that short-term nCPAP treatment is able to promote the recovery of vitamin D homeostasis in male patients with OSA. The mediation of sexual hormones in regulating vitamin D is a possible explanation of the lack of recovery of vitamin D homeostasis in female patients with OSA as it often affects postmenopausal women.
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