ArticleScientific reports2015
Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling.Cell stem cell · 2025Article
- Integrating collecting systems in human kidney organoids through fusion of distal nephron to ureteric bud.Cell stem cell · 2025Article
- Kidney organoids: steps towards better organization and function.Biochemical Society transactions · 2024Review
- Human iPSC-derived renal organoids engineered to report oxidative stress can predict drug-induced toxicity.iScience · 2022Article
- Modeling oxidative injury response in human kidney organoids.Stem cell research & therapy · 2022Article
- Combining Kidney Organoids and Genome Editing Technologies for a Better Understanding of Physiopathological Mechanisms of Renal Diseases: State of the Art.Frontiers in medicine · 2020Review
- Guided tissue organization and disease modeling in a kidney tubule array.Biomaterials · 2018Article
- Drug transporter expression profiling in a three-dimensional kidney proximal tubule in vitro nephrotoxicity model.Pflugers Archiv : European journal of physiology · 2018Article
- Engineered Kidney Tubules for Modeling Patient-Specific Diseases and Drug Discovery.EBioMedicine · 2018Article
- Adaptive self-organization in the embryo: its importance to adult anatomy and to tissue engineering.Journal of anatomy · 2018Review
- Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy.PloS one · 2018Article
- Asymmetric BMP4 signalling improves the realism of kidney organoids.Scientific reports · 2017Article
- Organ-on-a-chip for assessing environmental toxicants.Current opinion in biotechnology · 2017Review
- Bioengineered kidney tubules efficiently excrete uremic toxins.Scientific reports · 2016Article
- Self-organized Kidney Rudiments: Prospects for Better in vitro Nephrotoxicity Assays.Biomarker insights · 2015Review
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Authors and funding
3 authors.
Funding
Abstract
Recent advances in renal tissue engineering have shown that dissociated, early renogenic tissue from the developing embryo can self-assemble into morphologically accurate kidney-like organs arranged around a central collecting duct tree. In order for such self-assembled kidneys to be useful therapeutically or as models for drug screening, it is necessary to demonstrate that they are functional. One of the main functional characteristics of mature kidneys is transport of organic anions and cations into and out of the proximal tubule. Here, we show that the transport function of embryonic kidneys allowed to develop in culture follows a developmental time-course that is comparable to embryonic kidney development in vivo. We also demonstrate that serially-reaggregated engineered kidneys can transport organic anions and cations through specific uptake and efflux channels. These results support the physiological relevance of kidneys grown in culture, a commonly used model for kidney development and research, and suggest that serially-reaggregated kidneys self-assembled from separated cells have some functional characteristics of intact kidneys.
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