ArticleUltrasound in medicine & biology2015
On the relationship between microbubble fragmentation, deflation and broadband superharmonic signal production.
Article in Ultrasound in medicine & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Evaluation of cavitation enhancements in low-boiling point (< -2°C) perfluorocarbon nanodroplet and microbubble mixtures using therapeutic ultrasound pulses.Ultrasonics sonochemistry · 2026Article
- A 9-Fr Endovascular Therapy Transducer With an Acoustic Metamaterial Lens for Rapid Stroke Thrombectomy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Determining Ultrasound Parameters for Bursting Polymer Microbubbles for Future Use in Spinal Cord Injury.Ultrasound in medicine & biology · 2024Article
- Enhanced cavitation dose and reactive oxygen species production in microbubble-mediated sonodynamic therapy for inhibition of Escherichia coli and biofilm.Ultrasonics sonochemistry · 2024Article
- Superharmonic and Microultrasound Imaging With Plane Wave Beamforming Techniques.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components.Bioactive materials · 2023Article
- Targeted Delivery of Salusin-α Into Rabbit Carotid Arterial Endothelium Using SonoVue.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2022Article
- An Analysis of Sonothrombolysis and Cavitation for Retracted and Unretracted Clots Using Microbubbles Versus Low-Boiling-Point Nanodroplets.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Improving Release of Liposome-Encapsulated Drugs with Focused Ultrasound and Vaporizable Droplet-Liposome Nanoclusters.Pharmaceutics · 2021Article
- A Comparison of Sonothrombolysis in Aged Clots between Low-Boiling-Point Phase-Change Nanodroplets and Microbubbles of the Same Composition.Ultrasound in medicine & biology · 2020Article
- Visualization of Microvascular Angiogenesis Using Dual-Frequency Contrast-Enhanced Acoustic Angiography: A Review.Ultrasound in medicine & biology · 2020Review
- Contrast-enhanced ultrasound for quantification of tissue perfusion in humans.Microcirculation (New York, N.Y. : 1994) · 2020Review
- In Vitro Superharmonic Contrast Imaging Using a Hybrid Dual-Frequency Probe.Ultrasound in medicine & biology · 2019Article
- Assessment of the Superharmonic Response of Microbubble Contrast Agents for Acoustic Angiography as a Function of Microbubble Parameters.Ultrasound in medicine & biology · 2019Article
- Formulation and Characterization of Chemically Cross-linked Microbubble Clusters.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Candle Soot Carbon Nanoparticles in Photoacoustics: Advantages and Challenges for Laser Ultrasound Transmitters.IEEE nanotechnology magazine · 2019Article
- A Dual-Frequency Colinear Array for Acoustic Angiography in Prostate Cancer Evaluation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2018Article
- Dual-Frequency Piezoelectric Endoscopic Transducer for Imaging Vascular Invasion in Pancreatic Cancer.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017Article
- Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis.Scientific reports · 2017Article
- High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography.Annals of biomedical engineering · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Acoustic angiography imaging of microbubble contrast agents uses the superharmonic energy produced from excited microbubbles and enables high-contrast, high-resolution imaging. However, the exact mechanism by which broadband harmonic energy is produced is not fully understood. To elucidate the role of microbubble shell fragmentation in superharmonic signal production, simultaneous optical and acoustic measurements were performed on individual microbubbles at transmit frequencies from 1.75 to 3.75 MHz and pressures near the shell fragmentation threshold for microbubbles of varying diameter. High-amplitude, broadband superharmonic signals were produced with shell fragmentation, whereas weaker signals (approximately 25% of peak amplitude) were observed in the presence of shrinking bubbles. Furthermore, when populations of stationary microbubbles were imaged with a dual-frequency ultrasound imaging system, a sharper decline in image intensity with respect to frame number was observed for 1-μm bubbles than for 4-μm bubbles. Finally, in a study of two rodents, increasing frame rate from 4 to 7 Hz resulted in decreases in mean steady-state image intensity of 27% at 1000 kPa and 29% at 1300 kPa. Although the existence of superharmonic signals when bubbles shrink has the potential to prolong the imaging efficacy of microbubbles, parameters such as frame rate and peak pressure must be balanced with expected re-perfusion rate to maintain adequate contrast during in vivo imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.