Observational studyJournal of the American Society of Nephrology : JASN2015
Risk of Adverse Pregnancy Outcomes in Women with CKD.
Observational study in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
145 citing papers in PubMed, 9 syntheses or guidelines pooled it, 340 citations in OpenAlex.
- 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2026Guideline
- Pregnancy occurring in AA amyloidosis: a series of 27 patients including 3 new French cases.Journal of nephrology · 2024Pooled it
- Systematic review of pregnancy and renal outcomes for women with chronic kidney disease receiving assisted reproductive therapy.Journal of nephrology · 2022Pooled it
- Maternal and neonatal outcomes of pregnancy complicated by urolithiasis: a systematic review and meta-analysis.Journal of nephrology · 2021Pooled it
- Kidney biopsy guidebook 2020 in Japan.Clinical and experimental nephrology · 2021Guideline
- Long-term Graft Survival and Graft Function Following Pregnancy in Kidney Transplant Recipients: A Systematic Review and Meta-analysis.Transplantation · 2020Pooled it
- Clinical practice guideline on pregnancy and renal disease.BMC nephrology · 2019Guideline
- A best-practice position statement on pregnancy after kidney transplantation: focusing on the unsolved questions. The Kidney and Pregnancy Study Group of the Italian Society of Nephrology.Journal of nephrology · 2018Guideline
- A best practice position statement on the role of the nephrologist in the prevention and follow-up of preeclampsia: the Italian study group on kidney and pregnancy.Journal of nephrology · 2017Guideline
- Clinical practice recommendations for the diagnosis and management of nephropathic cystinosis.Nature reviews. Nephrology · 2026Review
- Multifetal Pregnancies in Women with CKD: Risk Assessment and Indications for Counseling.Kidney360 · 2026Article
- Pregnancy outcomes and risk factors analysis in patients with chronic kidney disease: a nested case-control study.BMC pregnancy and childbirth · 2026Article
- [Treatment principles and long-term management of glomerulonephritides].Innere Medizin (Heidelberg, Germany) · 2026Review
- Association between Maternal Midterm eGFR and Newborn Birth Weight: Seiiku Boshi Cohort Study.Kidney360 · 2026Article
- Opportunities for renal genetic evaluation among pregnant patients with kidney disease.Pregnancy (Hoboken, N.J.) · 2026Article
- The Prevalence of Cardiovascular-Kidney-Metabolic Syndrome: A Review of Published Estimates and New Findings from BRFSS Surveys.Cardiovasc medicine (Basel, Switzerland) · 2026Article
- Risk of congenital malformation in newborns from mothers with kidney diseases in a nationwide cohort study.Communications medicine · 2026Article
- Health Care Utilization Among Pregnant Women With Pre-existing Kidney Disease: A Retrospective Cohort Analysis.Kidney medicine · 2025Article
- Early-mid pregnancy renal parameters and adverse pregnancy outcomes in women with early stage CKD: a case series.Journal of nephrology · 2025Article
- Kidney and Pregnancy: A Comprehensive Review.Clinics and practice · 2025Review
85 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CKD is increasingly prevalent in pregnancy. In the Torino-Cagliari Observational Study (TOCOS), we assessed whether the risk for adverse pregnancy outcomes is associated with CKD by comparing pregnancy outcomes of 504 pregnancies in women with CKD to outcomes of 836 low-risk pregnancies in women without CKD. The presence of hypertension, proteinuria (>1 g/d), systemic disease, and CKD stage (at referral) were assessed at baseline. The following outcomes were studied: cesarean section, preterm delivery, and early preterm delivery; small for gestational age (SGA); need for neonatal intensive care unit (NICU); new onset of hypertension; new onset/doubling of proteinuria; CKD stage shift; "general" combined outcome (preterm delivery, NICU, SGA); and "severe" combined outcome (early preterm delivery, NICU, SGA). The risk for adverse outcomes increased across stages (for stage 1 versus stages 4-5: "general" combined outcome, 34.1% versus 90.0%; "severe" combined outcome, 21.4% versus 80.0%; P<0.001). In women with stage 1 CKD, preterm delivery was associated with baseline hypertension (odds ratio [OR], 3.42; 95% confidence interval [95% CI], 1.87 to 6.21), systemic disease (OR, 3.13; 95% CI, 1.51 to 6.50), and proteinuria (OR, 3.69; 95% CI, 1.63 to 8.36). However, stage 1 CKD remained associated with adverse pregnancy outcomes (general combined outcome) in women without baseline hypertension, proteinuria, or systemic disease (OR, 1.88; 95% CI, 1.27 to 2.79). The risk of intrauterine death did not differ between patients and controls. Findings from this prospective study suggest a "baseline risk" for adverse pregnancy-related outcomes linked to CKD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.