Evidence map›Paper›PMID 25766503›Full record

ArticleMolecular and cellular endocrinology2015

Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) regulates glucocorticoid action in adipocytes.

Margo P Emont, Stelios Mantis, Jonathan H Kahn, Michael Landeche, Xuan Han, Robert M Sargis, Ronald N Cohen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Impacts of Alternative Splicing Events on the Differentiation of Adipocytes.International journal of molecular sciences · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Margo P EmontSection of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD 8126, Chicago, IL 60637, USA.
Stelios MantisSection of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD 8126, Chicago, IL 60637, USA.
Jonathan H KahnSection of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD 8126, Chicago, IL 60637, USA.
Michael LandecheSection of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD 8126, Chicago, IL 60637, USA.
Xuan HanSection of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD 8126, Chicago, IL 60637, USA.
Robert M SargisSection of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD 8126, Chicago, IL 60637, USA.
Ronald N CohenSection of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD 8126, Chicago, IL 60637, USA. Electronic address: roncohen@medicine.bsd.uchicago.edu.
University of Chicago · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Role of SMRT and NCoR in adipocyte differentation and functionR01DK078125 · NIDDK · UNIVERSITY OF CHICAGO · PI COHEN, RONALD N · 2008 to 2012
$1.5M
NCATS NIH HHS UL1 TR000430NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK078125PHS HHS NIDDK R01DK078125
6 · The paper itself

Abstract

Local modulation of glucocorticoid action in adipocytes regulates adiposity and systemic insulin sensitivity. However, the specific cofactors that mediate glucocorticoid receptor (GR) action in adipocytes remain unclear. Here we show that the silencing mediator of retinoid and thyroid hormone receptors (SMRT) is recruited to GR in adipocytes and regulates ligand-dependent GR function. Decreased SMRT expression in adipocytes in vivo increases expression of glucocorticoid-responsive genes. Moreover, adipocytes with decreased SMRT expression exhibit altered glucocorticoid regulation of lipolysis. We conclude that SMRT regulates the metabolic functions of GR in adipocytes in vivo. Modulation of GR-SMRT interactions in adipocytes represents a novel approach to control the local degree of glucocorticoid action and thus influence adipocyte metabolic function.

Indexed as

AdipocytesAdipose TissueAnimalsDexamethasoneEpididymisFibroblastsGene Expression RegulationGenes, ReporterLipolysisLuciferasesMaleMiceNuclear ProteinsNuclear Receptor Co-Repressor 2Phosphatidate PhosphatasePrimary Cell CultureDexamethasoneDsip1 protein, mouseLpin1 protein, mouseLuciferasesNcor2 protein, mouseNuclear ProteinsNuclear Receptor Co-Repressor 2Phosphatidate PhosphataseReceptors, GlucocorticoidReceptors, Thyroid HormoneTranscription FactorsAdipocyteCorepressorGlucocorticoidNuclear receptor

Identifiers

PMID25766503
PMCPMC4390535
OpenAlexW2064428904

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.