ArticleArchives of oral biology2015
Radiotherapy effect on nano-mechanical properties and chemical composition of enamel and dentine.
Article in Archives of oral biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Effectiveness of glass ionomer cements in the restorative treatment of radiation-related caries - a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- The impact of head and neck radiotherapy on the dentine-enamel junction: a systematic review.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- Impact of radiotherapy on the morphological and compositional structure of intra-radicular dentin.Brazilian dental journalTrial
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- Damage of irradiated teeth by ultrasonic scaling: an in vitro study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Microstructural changes in irradiated teeth revealed by swept-source optical coherence tomography.Scientific reports · 2026Article
- Dose-Dependent Effects of Simulated Clinical Radiotherapy on the Structure and Properties of Root Dentine.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Clinically relevant radiation therapy doses and obturation techniques modulate the adhesive performance of a resin-based sealer: interfacial integrity and bond strength analyses.Clinical oral investigations · 2026Article
- The reinforcing effect of anti-caries treatments on acidic challenge resistance of irradiated enamel.PloS one · 2026Article
- Does radiotherapy compromise root canal sealer penetration? An in vitro confocal laser microscopy study.Clinical oral investigations · 2025Article
- Effect of gamma radiation on human enamel chemical and physical properties.BMC oral health · 2025Article
- Effect of different protocols in preventing demineralization in irradiated human enamel, in vitro study.BMC oral health · 2025Article
- Impact of radiotherapy in chemical composition and mechanical properties of human cervical dentin: an in vitro study.Journal of applied oral science : revista FOB · 2025Article
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- Article
- The influence of different radiotherapy doses on the mechanical properties and microstructure of the enamel and dentin of human premolar teeth.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024Article
- Consequences of hyposalivation in relation to cancer treatment and early management of radiation-induced caries: case reports.British dental journal · 2024Article
- Effect of different approaches of direct radiation on the surface structure and caries susceptibility of enamel.Scientific reports · 2024Article
- Ultrasonic activation of adhesive systems increases bond strength and intratubular penetration of resin cement in root dentin subjected to radiation therapy.Clinical oral investigations · 2024Article
- Are Discrepancies in the Amount of Radiation Delivered to Target Neoplastic Cells and Teeth in Cases of Head and Neck Cancer Significant Considerations in Laboratory Research?European journal of dentistry · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo understand radiotherapy-induced dental lesions characterized by enamel loss or delamination near the dentine-enamel junction (DEJ), this study evaluated enamel and dentine nano-mechanical properties and chemical composition before and after simulated oral cancer radiotherapy.
designSections from seven non-carious third molars were exposed to 2 Gy fractions, 5 days/week for 7 weeks for a total of 70 Gy. Nanoindentation was used to evaluate Young's modulus, while Raman microspectroscopy was used to measure protein/mineral ratios, carbonate/phosphate ratios, and phosphate peak width. All measures were completed prior to and following radiation at the same four buccal and lingual sites 500 and 30 μm from the DEJ in enamel and dentine (E-500, E-30, D-30 and D-500).
resultsThe elastic modulus of enamel and dentine was significantly increased (P ≤ 0.05) following radiation. Based on Raman spectroscopic analysis, there was a significant decrease in the protein to mineral ratio (2931/430 cm(-1)) following radiation at all sites tested except at D-500, while the carbonate to phosphate ratio (1070/960 cm(-1)) increased at E-30 and decreased at D-500. Finally, phosphate peak width as measured by FWHM at 960 cm(-1) significantly decreased at both D-30 and D-500 following radiation.
conclusionsSimulated radiotherapy produced an increase in the stiffness of enamel and dentine near the DEJ. Increased stiffness is speculated to be the result of the radiation-induced decrease in the protein content, with the percent reduction much greater in the enamel sites. Such changes in mechanical properties and chemical composition could potentially contribute to DEJ biomechanical failure leading to enamel delamination that occurs post-radiotherapy. However, other analyses are required for a better understanding of radiotherapy-induced effects on tooth structure to improve preventive and restorative treatments for oral cancer patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.