Evidence map›Paper›PMID 25766289›Full record

ArticleCell host & microbe2015

Inflammasomes in aspergillosis--it takes two to tango.

Jeffrey Tomalka, Amy G Hise

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jeffrey TomalkaDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Amy G HiseDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Geriatric Research Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA; Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: amy.hise@case.edu.
Geriatric Research Education and Clinical Center · USUniversity School · US

Funding

Immunology Training Program-PredoctoralT32AI089474 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2010 to 2025
$3.4M
Host Defense in Oral CandidiasisR01DE018279 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI HISE, AMY G · 2007 to 2011
$1.7M
Role of inflammasomes in mucosal and systemic candidiasis.I01BX002607 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI HISE, AMY G · 2015 to 2018
–
BLRD VA I01 BX002607NIAID NIH HHS T32 AI089474NIDCR NIH HHS R01 DE018279
6 · The paper itself

Abstract

Intracellular inflammasome complexes regulate critical cytokine responses to infections. In this issue of Cell Host & Microbe,Karki et al. (2015) show that protection against the fungus Aspergillus requires the combined efforts of the NLRP3 and AIM2 inflammasomes and involves both caspase-1 and caspase-8.

Indexed as

AnimalsAspergillus fumigatusCarrier ProteinsDNA-Binding ProteinsInflammasomesCarrier ProteinsDNA-Binding ProteinsInflammasomes

Identifiers

PMID25766289
OpenAlexW2049787543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.