Evidence map›Paper›PMID 25766287›Full record

ArticleCell host & microbe2015

RIG-I works double duty.

Ying Kai Chan, Michaela U Gack

Open access · bronzeAbstract readComment
In one paragraph

Article in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ying Kai ChanDepartment of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Michaela U GackDepartment of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: michaela_gack@hms.harvard.edu.
Harvard University · US

Funding

Regulatory mechanisms of the MDA5-mediated antiviral interferon responseR21AI097699 · NIAID · HARVARD MEDICAL SCHOOL · PI GACK, MICHAELA ULRIKE · 2012 to 2013
$481k
NIAID NIH HHS R21 AI097699
6 · The paper itself

Abstract

The pathogen sensor RIG-I recognizes viral RNA and signals to induce an antiviral response. In this issue of Cell Host & Microbe, Weber et al. (2015), along with recent work by Sato et al. (2015), demonstrate that RIG-I directly inhibits viral replication independent of antiviral signaling.

Indexed as

AnimalsFemaleGene Products, polHepatitis B, ChronicHepatitis B virusHepatocytesHumansLiverMembrane ProteinsNerve Tissue ProteinsRNA, ViralGene Products, polMembrane ProteinsNerve Tissue ProteinsRNA, Viral

Identifiers

PMID25766287
PMCPMC5072393
OpenAlexW2007992229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.