ArticleHuman brain mapping2015
A potential role for the midbrain in integrating fat-free mass determined energy needs: An H2 (15) O PET study.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Variability of physiological brain perfusion in healthy subjects - A systematic review of modifiers. Considerations for multi-center ASL studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Pooled it
- An Increase in Fat-Free Mass is Associated with Higher Appetite and Energy Intake in Older Adults: A Randomised Control Trial.Nutrients · 2021Trial
- Genetic variation in lean body mass, changes of appetite and weight loss in response to diet interventions: The POUNDS Lost trial.Diabetes, obesity & metabolism · 2020Trial
- The consequences of exercise-induced weight loss on food reinforcement. A randomized controlled trial.PloS one · 2020Trial
- A synergistic effect of secondhand smoke with vitamin D deficiency on cognitive impairment in older adults: a cross sectional study.Frontiers in nutrition · 2025Article
- Fat-free mass and resting metabolic rate are determinants of energy intake: implications for a theory of appetite control.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Biological and psychological mediators of the relationships between fat mass, fat-free mass and energy intake.International journal of obesity (2005) · 2019Article
- Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Collateral fattening in body composition autoregulation: its determinants and significance for obesity predisposition.European journal of clinical nutrition · 2018Review
- Influence of Muscle Mass and Outdoor Environmental Factors on Appetite and Satiety Feeling in Young Japanese Women.International journal of environmental research and public health · 2018Article
- The obese brain as a heritable phenotype: a combined morphometry and twin study.International journal of obesity (2005) · 2017Article
- Reprogramming of defended body weight after Roux-En-Y gastric bypass surgery in diet-induced obese mice.Obesity (Silver Spring, Md.) · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Little is known on how sensing of energy needs is centrally represented, integrated, and translated into the behavioral aspects of energy homeostasis. Fat free mass (FFM) is the major determinant of energy expenditure. We investigated how interindividual variances in FFM relate to neuronal activity in humans. Healthy adults (n = 64, 21F/43M; age 31.3 ± 9.1y; percentage of body fat [PFAT] 25.6 ± 10.7%; BMI 30.4 ± 9) underwent a 36h fast and subsequent H(2) (15) O positron emission tomographic (PET) measurement of regional cerebral blood flow (rCBF). Multiple variable regression analysis revealed significant associations of FFM with rCBF within the midbrain [including parts of the periaqueductal gray (PAG), ventral tegmental area (VTA), thalamic and hypothalamic regions], the bilateral parahippocampal region, left anterior cingulate, left insular cortex, right cerebellum, and distinct regions within the temporal and occipital cortex. In contrast, no significant associations were found for fat mass (FM). We investigated the potential functional-anatomical link between FFM and central regulation of food intake by performing a conjunction analysis of FFM and the perceived hunger feelings. This showed a significant overlap within the midbrain PAG. Mediation analysis demonstrated a significant indirect effect of FFM on hunger with PAG rCBF as mediator. Most regions we found to be associated with FFM form part in ascending homeostatic pathways and cortical circuitries implicated in the regulation of basic bodily functions indicating a potential role of these central networks in the integration of FFM determined energy needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.