Evidence map›Paper›PMID 25766240›Full record

ReviewScience (New York, N.Y.)2015

Modeling infectious disease dynamics in the complex landscape of global health.

Hans Heesterbeek, Roy M Anderson, Viggo Andreasen, Shweta Bansal, Daniela De Angelis, Chris Dye, Ken T D Eames, W John Edmunds, Simon D W Frost, Sebastian Funk and 13 more

Abstract readReview
In one paragraph

Review in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 316 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
316citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

316 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Real-time spatiotemporal tracking of infectious outbreaks in confined environments with a host-pathogen agent-based system.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  19. Review
  20. Article

256 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Hans HeesterbeekFaculty of Veterinary Medicine, University of Utrecht, Utrecht, Netherlands. j.a.p.heesterbeek@uu.nl.
Roy M AndersonSchool of Public Health, Imperial College, London, UK.
Viggo AndreasenRoskilde University, Roskilde, Denmark.
Shweta BansalGeorgetown University, Washington, DC, USA.
Daniela De AngelisMRC Biostatistics Unit, Cambridge, UK.
Chris DyeWHO, Geneva, Switzerland.
Ken T D EamesCentre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene Tropical Medicine, London, UK.
W John EdmundsCentre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene Tropical Medicine, London, UK.
Simon D W FrostUniversity of Cambridge, Cambridge, UK.
Sebastian FunkGeorgetown University, Washington, DC, USA.
T Deirdre HollingsworthSchool of Life Sciences, University of Warwick, UK. School of Tropical Medicine, University of Liverpool, UK.
Thomas HouseWarwick Mathematics Institute, University of Warwick, Coventry, UK.
Valerie IshamDepartment of Statistical Science, University College London, London, UK.
Petra KlepacUniversity of Cambridge, Cambridge, UK.
Justin LesslerDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
James O Lloyd-SmithDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA.
C Jessica E MetcalfDepartment of Zoology, University of Oxford, Oxford, UK, and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
Denis MollisonHeriot-Watt University, Edinburgh, UK.
Lorenzo PellisWarwick Mathematics Institute, University of Warwick, Coventry, UK.
Juliet R C PulliamDepartment of Biology-Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA. Division of International Epidemiology and Population Studies, Fogarty International Center, NIH, Bethesda, MD, USA.
Mick G RobertsInstitute of Natural and Mathematical Sciences, Massey University, Auckland, New Zealand.
Cecile ViboudDivision of International Epidemiology and Population Studies, Fogarty International Center, NIH, Bethesda, MD, USA.
Isaac Newton Institute IDD Collaboration

Funding

Scientific and Technical Computing CoreP2CHD047879 · NICHD · PRINCETON UNIVERSITY · PI MASSEY, DOUGLAS S · 2014 to 2018
$2.0M
Models for synthesising molecular, clinical and epidemiological data, and translaU01GM110721 · NIGMS · IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · PI CAUCHEMEZ, SIMON, FERGUSON, NEIL MORRIS · 2014 to 2018
$1.9M
Medical Research Council MC_U105260556Medical Research Council MR/K021680/1NICHD NIH HHS P2C HD047879NIGMS NIH HHS U01 GM110721World Health Organization 001
6 · The paper itself

Abstract

Despite some notable successes in the control of infectious diseases, transmissible pathogens still pose an enormous threat to human and animal health. The ecological and evolutionary dynamics of infections play out on a wide range of interconnected temporal, organizational, and spatial scales, which span hours to months, cells to ecosystems, and local to global spread. Moreover, some pathogens are directly transmitted between individuals of a single species, whereas others circulate among multiple hosts, need arthropod vectors, or can survive in environmental reservoirs. Many factors, including increasing antimicrobial resistance, increased human connectivity and changeable human behavior, elevate prevention and control from matters of national policy to international challenge. In the face of this complexity, mathematical models offer valuable tools for synthesizing information to understand epidemiological patterns, and for developing quantitative evidence for decision-making in global health.

Indexed as

Communicable DiseasesGlobal HealthModels, BiologicalPublic HealthAnimalsBasic Reproduction NumberCoinfectionCommunicable Disease ControlCommunicable Diseases, EmergingDisease OutbreaksHealth PolicyHemorrhagic Fever, EbolaHumansZoonoses

Identifiers

PMID25766240
PMCPMC4445966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.