ArticleScience (New York, N.Y.)2015
Synthesis of many different types of organic small molecules using one automated process.
Article in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.
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Who cites it
143 citing papers in PubMed.
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- AutoLabs: cognitive multi-agent systems with self-correction for autonomous chemical experimentation.Scientific reports · 2026Article
- RobInHood: a robotic chemist in a fume hood.Digital discovery · 2026Article
- Enhanced B-N coordinated dynamic boronate chemistry for recyclable thermosets with elevated stability.Nature communications · 2026Article
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- Regio-reversed alkenyl-arylation of ynamidesChemical science · 2026Article
- Artificial Intelligence Empowered New Materials: Discovery, Synthesis, Prediction to Validation.Nano-micro letters · 2026Review
- Highly selective and AI-predictable Se-N exchange chemistry between benzoselenazolones and boronic acids for programmable, parallel, and DNA-encoded library synthesis.Chemical science · 2026Article
- Illuminating the Interface of Blocc Chemistry and Data Science: An Introduction to K‑Nearest Neighbor Analysis and K‑Medoids Clustering.Journal of chemical education · 2025Article
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- Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology.Journal of the American Chemical Society · 2025Review
- Modular Synthetic Platform for the Elaboration of Fragments in Three Dimensions for Fragment-Based Drug Discovery.Journal of the American Chemical Society · 2025Article
- Automated Iterative N─C and C─C Bond Formation.Angewandte Chemie (International ed. in English) · 2025Article
- Universal peptide synthesis via solid-phase methods fused with chemputation.Nature communications · 2025Article
- Atom-by-Atom Iterative Synthetic Logic: Laying the Foundation for Programmable Automated Construction of Small Organic Molecules.ACS central science · 2025Review
- Reaction blueprints and logical control flow for parallelized chiral synthesis in the Chemputer.Nature communications · 2024Article
- Rapid, Homogenous, B-Alkyl Suzuki-Miyaura Cross-Coupling of Boronic Esters.The Journal of organic chemistry · 2024Article
- Minimizing higher-order aggregation maximizes iron mobilization by small molecules.Nature chemical biology · 2024Article
83 more citing papers are in PubMed but not listed here.
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9 authors.
Funding
Abstract
Small-molecule synthesis usually relies on procedures that are highly customized for each target. A broadly applicable automated process could greatly increase the accessibility of this class of compounds to enable investigations of their practical potential. Here we report the synthesis of 14 distinct classes of small molecules using the same fully automated process. This was achieved by strategically expanding the scope of a building block-based synthesis platform to include even C(sp3)-rich polycyclic natural product frameworks and discovering a catch-and-release chromatographic purification protocol applicable to all of the corresponding intermediates. With thousands of compatible building blocks already commercially available, many small molecules are now accessible with this platform. More broadly, these findings illuminate an actionable roadmap to a more general and automated approach for small-molecule synthesis.
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