ArticleBMC genomics2015
H2A.Z marks antisense promoters and has positive effects on antisense transcript levels in budding yeast.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- An intricate functional relationship between NuA4 and Sfp1 regulates ribosome biogenesis in response to nutrient availability.The Journal of biological chemistry · 2026Article
- Truncating the spliceosomal 'rope protein' Prp45 results in Htz1 dependent phenotypes.RNA biology · 2024Article
- Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors.Genes & development · 2021Article
- On and Off: Epigenetic Regulation ofPathogens (Basel, Switzerland) · 2021Review
- The histone variant H2A.Z in yeast is almost exclusively incorporated into the +1 nucleosome in the direction of transcription.Nucleic acids research · 2020Article
- Transposition favors the generation of large effect mutations that may facilitate rapid adaption.Nature communications · 2019Article
- Antisense transcriptional interference mediates condition-specific gene repression in budding yeast.Nucleic acids research · 2018Article
- The INO80 chromatin remodeler sustains metabolic stability by promoting TOR signaling and regulating histone acetylation.PLoS genetics · 2018Article
- Downstream promoter interactions of TFIID TAFs facilitate transcription reinitiation.Genes & development · 2017Article
- Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- INO80 represses osmostress induced gene expression by resetting promoter proximal nucleosomes.Nucleic acids research · 2017Article
- Arabidopsis SWI/SNF chromatin remodeling complex binds both promoters and terminators to regulate gene expression.Nucleic acids research · 2017Article
- The histone variant H2A.Z promotes efficient cotranscriptional splicing inGenes & development · 2017Article
- The Determinants of Directionality in Transcriptional Initiation.Trends in genetics : TIG · 2016Review
- Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis.Cell reports · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe histone variant H2A.Z, which has been reported to have both activating and repressive effects on gene expression, is known to occupy nucleosomes at the 5' ends of protein-coding genes.
resultsWe now find that H2A.Z is also significantly enriched in gene coding regions and at the 3' ends of genes in budding yeast, where it co-localises with histone marks associated with active promoters. By comparing H2A.Z binding to global gene expression in budding yeast strains engineered so that normally unstable transcripts are abundant, we show that H2A.Z is required for normal levels of antisense transcripts as well as sense ones. High levels of H2A.Z at antisense promoters are associated with decreased antisense transcript levels when H2A.Z is deleted, indicating that H2A.Z has an activating effect on antisense transcripts. Decreases in antisense transcripts affected by H2A.Z are accompanied by increased levels of paired sense transcripts.
conclusionsThe effect of H2A.Z on protein coding gene expression is a reflection of its importance for normal levels of both sense and antisense transcripts.
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