Evidence map›Paper›PMID 25765863›Full record

ReviewHuman reproduction update

Endometriosis: a high-risk population for major chronic diseases?

Marina Kvaskoff, Fan Mu, Kathryn L Terry, Holly R Harris, Elizabeth M Poole, Leslie Farland, Stacey A Missmer

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human reproduction update. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 10 pooled it
33.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 10 syntheses or guidelines pooled it, 422 citations in OpenAlex.

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  11. Article
  12. Article
  13. Inverse association between obesity and intestinal endometriosis: Findings from a cross-sectional study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Observational
  14. Article
  15. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Article
  16. Predictive markers of endometriosis: a future perspective.Archives of gynecology and obstetrics · 2026
    Review
  17. Article
  18. Review
  19. Often delayed and fractured, endometriosis care needs an overhaul.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Article
  20. Observational

148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Marina KvaskoffChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA Inserm U1018, Centre for Research in Epidemiology and Population Health (CESP), 'Nutrition, Hormones and Women's Health' Team, F-94805 Villejuif, France Univ. Paris Sud 11, UMRS 1018, F-94807 Villejuif, France Gustave Roussy, F-94805 Villejuif, France Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia marina.kvaskoff@channing.harvard.edu.
Fan MuDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Kathryn L TerryChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Holly R HarrisDepartment of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA Division of Nutritional Epidemiology, The National Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Elizabeth M PooleChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Leslie FarlandDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Stacey A MissmerChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Harvard University · USBrigham and Women's Hospital · USKarolinska Institutet · SE

Funding

Immunology, Inflammation, and EndometriosisR01HD057210 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI MISSMER, STACEY ANN · 2009 to 2012
$1.4M
Predoctoral Training Program in Reproductive, Perinatal & Pediatric EpidemiologyT32HD060454 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI MICHELS, KARIN B · 2010 to 2014
$1.1M
NICHD NIH HHS HD57210NICHD NIH HHS R01 HD057210NICHD NIH HHS T32HD060454
6 · The paper itself

Abstract

backgroundDespite an estimated prevalence of 10% in women, the etiology of endometriosis remains poorly understood. Over recent decades, endometriosis has been associated with risk of several chronic diseases, such as cancer, autoimmune diseases, asthma/atopic diseases and cardiovascular diseases. A deeper understanding of these associations is needed as they may provide new leads into the causes or consequences of endometriosis. This review summarizes the available epidemiological findings on the associations between endometriosis and other chronic diseases and discusses hypotheses for underlying mechanisms, potential sources of bias and methodological complexities.

methodsWe performed a comprehensive search of the PubMed/Medline and ISI Web of Knowledge databases for all studies reporting on the associations between endometriosis and other diseases published in English through to May 2014, using numerous search terms. We additionally examined the reference lists of all identified papers to capture any additional articles that were not identified through computer searches.

resultsWe identified 21 studies on the associations between endometriosis and ovarian cancer, 14 for breast cancer, 8 for endometrial cancer, 4 for cervical cancer, 12 for cutaneous melanoma and 3 for non-Hodgkin's lymphoma, as well as 9 on the links between endometriosis and autoimmune diseases, 6 on the links with asthma and atopic diseases, and 4 on the links with cardiovascular diseases. Endometriosis patients were reported to be at higher risk of ovarian and breast cancers, cutaneous melanoma, asthma, and some autoimmune, cardiovascular and atopic diseases, and at decreased risk of cervical cancer.

conclusionsIncreasing evidence suggests that endometriosis patients are at higher risk of several chronic diseases. Although the underlying mechanisms are not yet understood, the available data to date suggest that endometriosis is not harmless with respects to women's long-term health. If these relationships are confirmed, these findings may have important implications in screening practices and in the management and care of endometriosis patients.

Indexed as

Women's HealthAsthmaAutoimmune DiseasesBreast NeoplasmsCardiovascular DiseasesChronic DiseaseCutaneous Malignant MelanomaEndometriosisFemaleHumansLymphoma, Non-HodgkinMelanomaOvarian NeoplasmsPrevalenceRiskSkin Neoplasmsasthmaautoimmune diseasescancercardiovascular diseasesendometriosis

Identifiers

PMID25765863
PMCPMC4463000
OpenAlexW2151934245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.